Table 1 Top 10 structures from the "highly conserved set" based on structure conservation.
Group ID1 (CoV2) | Structure3 | ||
|---|---|---|---|
GO Entries4 | |||
3 (HSL3) (28.13) | NM_005321:721-785 NM_021062:401–431 NM_005319:704–732 NM_003526:412–438 NM_002105:545–578 NM_003516:510–534 #=GC SS_cons | AACC-C-AAAGGCTCTTTTCAGAGCCACCCA AACC-C-AAAGGCTCTTTTCAGAGCCACCTA AACC-CAAAAGGCTCTTTTCAGAGCCACC-A --CC-C-AAAGGCTCTTTTAAGAGCCACCCA A-CCAC-AAAGGCCCTTTTAAGGGCCACC-A -A-----AAAGGCTCTTTTCAGAGCCACCCA ..........((((((....))))))..... | HIST1H1E: histone cluster 1, H1e HIST1H2BB: histone cluster 1, H2bb HIST1H1C: histone cluster 1, H1c HIST1H2BC: histone cluster 1, H2bc H2AFX: H2A histone family, member X HIST2H2AA3: histone cluster 2, H2aa3 |
GO:0006334 (0) nucleosome assembly GO:0007001 (0) chromosome organization and biogenesis (sensu Eukarya). | |||
9 (IRE) (19.93) | NM_003234:3430–3460 NM_014585:197–237 NM_003234:3884–3912 NM_003234:3481–3509 NM_000032:13–36 NM_000146:20–40 #=GC SS_cons | TTTATCAGTGACAGAGTTCACTATAAA AACTTCAGCTACAGTGTTAGCTAAGTT ATTATCGGGAGCAGTGTCTTCCATAAT ATTATCGGAAGCAGTGCCTTCCATAAT GT--TCGTCCTCAGTGCAGGGCA--AC TG---CTTCAACAGTGTTTGGA---CG (((((.(((((......)))))))))) | TFRC: transferrin receptor (p90, CD71) SLC40A1: solute carrier family 40 (iron-regulated... TFRC: transferrin receptor (p90, CD71) TFRC: transferrin receptor (p90, CD71) ALAS2: aminolevulinate, delta-, synthase 2 (side... FTL: ferritin, light polypeptide |
GO:0006826 (0) iron ion transport GO:0006879 (0) iron ion homeostasis | |||
15 (17.40) | NM_015556:203–223 NM_018947:5349–5370 NM_000617:2349–2372 NM_018970:469–543 NM_173494:843–866 #=GC SS_cons | TCATTTAACCTTTTAAATGA AAATTTAACATTTTAAATTT TAATTTCTCAGTGGAAGTTA TATATTTTCAGTAAAATGTA TATTGTGACCATTTACAGTA ((((((((....)))))))) | SIPA1L1: signal-induced proliferation-associated 1 like... CYCS: cytochrome c, somatic, nuclear gene encoding SLC11A2: solute carrier family 11 (proton-coupled dival... GPR85: G protein-coupled receptor 85 CXorf41: chromosome X open reading frame 41 |
GO:0006810 (0.012265) transport | |||
17 (17.33) | NM_004441:3717–3813 NM_004443:3616–3640 NM_005398:2077–2107 NM_032827:2394–2416 #=GC SS_cons | TCTTCATATTGAAGA TCTTCATATTGAAGA CCTTCATATTGAAGG GCTTCAAATTGAAGT (((((.....))))) | EPHB1: EPH receptor B1 EPHB3: EPH receptor B3 PPP1R3C: protein phosphatase 1, regulatory (inhibitor) subu... ATOH8: atonal homolog 8 (Drosophila) |
GO:0007169 (0.00033) transmembrane receptor protein tyrosine kinase signaling pathway GO:0007165 (0.031793) signal transduction GO:0006468 (0.00927) protein amino acid phosphorylation | |||
19 (17.17) | NM_000314:502–530 NM_032564:144–170 NM_014751:110–164 NM_016233:2056–2074 #=GC SS_cons | CCTCCCGCTCCTGGAGCGGGGGG GCCCTGGCCCCGGGGGCCGGGGC -CGCTGGC-CCCGG-GTCAGCG- -CCTGTCC-CCCTG-GGGCGGG- ((((((((((...)))))))))) | PTEN: phosphatase and tensin homolog (mutated in multi... DGAT2: diacylglycerol O-acyltransferase homolog 2 (mou... MTSS1: metastasis suppressor 1 PADI3: peptidyl arginine deiminase, type III |
GO:0045786 (0.00108) negative regulation of cell cycle GO:0007049 (0.009836) cell cycle GO:0006629 (0.001806) lipid metabolism | |||
21 (17.00) | NM_000899:1060–1087 NM_015355:3606–3643 NM_003081:1331–1430 NM_002893:1613–1645 #=GC SS_cons | TTGCTTCATAAATGAAGCAG ATTCTTTATTTATAAAGGAT -TTATGCATTTATGCATGA- --GCTTGATTTATCAAGC-- ((((((((....)))))))) | KITLG: KIT ligand SUZ12: suppressor of zeste 12 homolog (Drosophila) SNAP25: synaptosomal-associated protein, 25 kDa RBBP7: retinoblastoma binding protein 7 |
GO:0016568 (0.000785) chromatin modification GO:0008283 (0.002712) cell proliferation | |||
23 (16.90) | NM_001546:1287–1309 NM_020834:2941–2962 NM_005643:1316–1339 NM_017617:8938–8965 NM_016120:2737–2778 #=GC SS_cons | CATCTATTGTTTAAAATAGATG CAGGTTTGGTTTTACAAACCTG CTTTAATGGTTTCACATTGAAG G-GATTTTGTTTAAAAAATC-T C--ATTT-GTTTAA-AAAT--G ((((((((......)))))))) | ID4: inhibitor of DNA binding 4, dominant negative ... KIAA1443: KIAA1443 TAF11: TAF11 RNA polymerase II, TATA box binding pr... NOTCH1: Notch homolog 1, translocation-associated (... RNF12: ring finger protein 12 |
GO:0016568 (0.000785) chromatin modification GO:0008283 (0.002712) cell proliferation | |||
25 (16.80) | NM_004625:1678–1700 NM_015508:3801–3828 NM_031371:4664–4722 NM_016513:2522–2555 NM_004744:2276–2294 NM_138290:1864–1884 #=GC SS_cons | ATATTAATTTATTTAATTAAA ATATTTATTTTTTTAATAAAA ATATTAAAGATTCTCTTTAAA ---TTAAAGTTTTTTTTTAA- ---TTAATTTTTCAAATTAA- ---GTAAATGTTTAATTTAC- ...((((((.....)))))). | WNT7A: wingless-type MMTV integration site family, me... TIPARP: TCDD-inducible poly(ADP-ribose) polymerase ARID4B: AT rich interactive domain 4B (RBP1-like), tr... ICK: intestinal cell (MAK-like) kinase, transcript va... LRAT: lecithin retinol acyltransferase (phosphatidylc... RPIB9: Rap2-binding protein 9 |
GO:0007275 (0.036763) development | |||
27 (16.57) | NM_000252:3053–3080 NM_003582:2041–2075 NM_001635:2828–2849 NM_001338:2060–2081 NM_152267:3108–3127 NM_006329:2418–2435 NM_005627:1871–1929 NM_000170:3730–3747 #=GC SS_cons | TTTTACAATGATTTGTAAAG TTTTTATATGATTATAAAAG GTTTTGCCTAATGGCAAAAC ATTTTTCTTATTAGAAAAAT ATTTTCACTGTTGTGAAAGT -TTTTGAGTATTTTTAAAA- -TCTTCCATATTTGGAAGA- -TTATTAGTATTCTAATAA- ((((((((....)))))))) | MTM1: myotubular myopathy 1 DYRK3: dual-specificity tyrosine-(Y)-phosphorylation r... AMPH: amphiphysin (Stiff-Man syndrome with breast canc... CXADR: coxsackie virus and adenovirus receptor FLJ38628: hypothetical protein FLJ38628 FBLN5: fibulin 5 SGK: serum/glucocorticoid regulated kinase GLDC: glycine dehydrogenase (decarboxylating; glycine ... |
GO:0007155 (0.027609) cell adhesion | |||
29 (16.30) | NM_002025:8958–8980 NM_014506:1434–1458 NM_014417:1285–1350 NM_007011:2104–2126 NM_004215:1327–1350 #=GC SS_cons | GCTGATGCTTTCAGC GCTGTTCTTTGCAGC -CTCCTCCTGGGAG- -CTCTTCCTGGGAG- -CTAGTGTTTCTAG- (((((.....))))) | AFF2: AF4/FMR2 family, member 2 TOR1B: torsin family 1, member B (torsin B) BBC3: BCL2 binding component 3 ABHD2: abhydrolase domain containing 2 EBAG9: estrogen receptor binding site associated, antigen, 9... |
GO:0006915 (0.011186) apoptosis | |||