Genomic maps of AIS subfamilies. The chromosomes of the human genome from chromosome 1 (chr1) to chromosomes X, Y (chrX, Y) are arranged in a circle (blue line). Red lines connect the genomic map positions of the members in each subfamily: (A) JAK, Janus kinase; (B) SOS, son of sevenless homolog; (C) SHC, SHC (Src homology 2 domain containing)-transforming protein; and (D) VAV, vav oncogene. Gray lines connect the genomic map positions of the genes in each BV paralogous pair (a paralogous pair that were formed at the Base of the Vertebrate lineage) of paralogons. Additional File 7 contains the genomic maps of all AIS subfamilies.