Skip to main content
Figure 9 | BMC Genomics

Figure 9

From: Comparative analysis of transcriptional profiling of CD3+, CD4+ and CD8+ T cells identifies novel immune response players in T-Cell activation

Figure 9

GZMB was upregulated continuously in all three populations. (A) Transcription profile of significantly regulated granzymes (GZMB, -A, -H, and -K). Color denotes degree of differential expression compared to 0 hour (saturated red = 3-fold up-regulation, saturated green = 3-fold down-regulation, black = unchanged, gray = no data available). Expression data shown are averages from three independent biological experiments for each T-cell population.(B) Intracellular protein expression profiles of GZMB in the CD4+ and CD8+ subsets. CD4+ T cells and CD8+ T cells were selected, stimulated (by anti-CD3/anti-CD28 antibodies), cultured separately and harvested at the indicated timepoints of culture to analyze the protein expression via by flow cytometric assays. Data from four independent CD4+ and CD8+ T-cell experiments, E8–E11, are shown.

Back to article page