Skip to main content

Table 2 Evolutionary sequence conservation of human TFBS.

From: Evolutionary rates and patterns for human transcription factor binding sites derived from repetitive DNA

Category

Site

Contact

Context

Non-repetitive

0.407 ± 0.085

0.410 ± 0.074

0.400 ± 0.110

All repeats

0.115 ± 0.042

0.130 ± 0.041

0.088 ± 0.045

All SSR

0.170 ± 0.056

0.183 ± 0.052

0.145 ± 0.062

All TEs

0.047 ± 0.026

0.059 ± 0.026

0.028 ± 0.026

Alu

0.002 ± 0.002

0.003 ± 0.003

0.002 ± 0.001

MIR

0.028 ± 0.017

0.048 ± 0.026

0.003 ± 0.004

L1

0.068 ± 0.063

0.077 ± 0.068

0.047 ± 0.052

All other LINEs

0.066 ± 0.018

0.095 ± 0.022

0.012 ± 0.011

LTR

0.141 ± 0.076

0.145 ± 0.042

0.136 ± 0.119

DNA

0.043 ± 0.029

0.057 ± 0.038

0.016 ± 0.009

  1. Average (± standard deviation) base-by-base conservation levels are shown for different categories, non-repetitive and repetitive, of human TFBS. TFBS derived from repetitive DNA are broken down SSR versus TE-derived, and TE-derived TFBS are divided into specific classes/families of elements. Base-by-base conservation levels were averaged separately across entire sites, and across contact versus context positions.