Table 1 Motifs used in the screening of DRB1-e2.

Polypurine/-pyrimidine tract

5'-RRRRR-3'/5'-YYYYY-3'

[47, 19, 48, 49]

Alternating purine-pyrimidine tract

5'-RYRYR-3'/5'-YRYRY-3'

[19, 50]

Immunoglobulin heavy chain class switch repeats

5'-GAGCT-3'/5'-AGCTC-3'

[51, 49]

5'-GGGCT-3'/5'-AGCCC-3'

5'-GGGGT-3'/5'-ACCCC-3'

5'-TGGGG-3'/5'-CCCCA-3'

5'-TGAGC-3'/5'-GCTCA-3'

DNA polymerase arrest site

5'-WGGAG-3'/5'-CTCCW-3'

[49]

Deletion hotspot consensus

5'-TGRRKM-3'/5'-KMYYCA-3'

[28, 49]

Heptamer recombination signal

5'-CACAGTG-3'/5'-CACTGTG-3'

[22]

Nonamer recombination signal

5'-ACAAAAACC-3'/5'-GGTTTTTGT-3'

[22]

Chi-like sequence

5'-GCTGGGG-3'/5'-CCCCAGC-3'

[40, 52]

Chi-like sequence

5'-CCAG-3'/5'-CTGG-3'

[53, 54]

Chi-like sequence

5'-GCWGGWGG-3'/5'-CCWCCWGC-3'

[55]

Topoisomerase I consensus cleavage sites

5'-CAT-3'/5'-ATG-3'

[56]

5'-CTY-3'/5'-RAG-3'

5'-GTY-3'/5'-RAC-3'

DNA polymerase A pause site core sequence

5'-GAG-3'/5'-CTC-3'

[57]

5'-ACG-3'/5'-CGT-3'

DNA polymerase A/B frameshift hotspots

5'-TGGNGT-3'/5'-ACNCCA-3'

[58, 59]

Vertebrate topoisomerase II consensus cleavage site

5'-RNYNNCNNGYNGKTNYNY-3'/

[60, 61]

5'-RNRNAMCNRCNNGNNTNY-3'

Human hypervariable minisatellite core sequence

5'-GGGCAGGANG-3'/5'-CNTCCTGCCC-3'

[62]

DNA polymerase A frameshift hotspots

5'-TCCCCC-3'/5'-GGGGGA-3'

[59, 63]

DNA polymerase B frameshift hotspots

5'-TTTT-3'/5'-AAAA-3'

[58]

Indel hotspot

5'-GTAAGT-3'/5'-ACTTAC-3'

[64]

Hotspot motif

5'-CCTCCCT-3'/5'-AGGGAGG-3'

[63]

Repeat element motif

5'-CCCCACCCC-3'/5'-GGGGTGGGG-3'

[63]

Double strand break-generating motif

5'-TGGGGG-3'/5'-CCCCCA-3'

[63]