From: Sequence features of HLA-DRB1 locus define putative basis for gene conversion and point mutations
Motif description | Motif sequence | Position | Not present in |
---|---|---|---|
Polypurine tract | 5'-RRRRR(RRR)-3' | 88–95 |  |
 |  | 121–125a |  |
 |  | 178–184 |  |
 |  | 246–250 |  |
Polypyrimidine tract | 5'-YYYYY-3' | 5–10 |  |
 |  | 36–41 |  |
Immunoglobulin heavy chain class switch repeat | 5'-GAGCT-3' | 141–145 | DRB1*0328 |
 |  | 248–252 | DRB1*0452 |
 | 5'-TGGGG-3' | 145–149 | DRB1*07 |
Deletion hotspot consensus | 5'-TGAAGA-3' | 37–42b |  |
 | 5'-TGRRKM-3' | 145–150 | DRB1*07 |
 |  | 250–255b |  |
Chi-like sequence | 5'-GCTGGGG-3' | 143–149 | DRB1*07 |
 | 5'-CTGG-3' | 144–147b | DRB1*07 |
 |  | 167–170b | DRB1*0705 |
 |  | 176–179 |  |
Topoisomerase I consensus cleavage site | 5'-CTY-3' | 38–40 |  |
 |  | 251–253 | DRB1*0423, *0452 |
 | 5'-GTY-3' | 4–6 |  |
 |  | 31–33 |  |
 |  | 47–49b |  |
 |  | 108–110b |  |
 |  | 114–116b |  |
 |  | 171–173b |  |
 |  | 183–185b |  |
 |  | 213–215b |  |
 |  | 231–233b |  |
DNA polymerase a pause site core sequence | 5'-GAG-3' | 51–53 | DRB1*0439 |
 |  | 121–123 |  |
 |  | 246–251 (2×) |  |
 |  | 268–270 |  |
 | 5'-ACG-3' | 2–4 |  |
 |  | 115–117 |  |
 |  | 116–118b |  |
Deletion hotspot | 5'-YYYTG-3' | 7–11 |  |
 |  | 177–181b | DRB1*0705 |
 |  | 187–191 | DRB1*1374 |