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Table 2 Motifs previously identified in other genes found in the DRB1-e2

From: Sequence features of HLA-DRB1 locus define putative basis for gene conversion and point mutations

Motif description Motif sequence Position Not present in
Polypurine tract 5'-RRRRR(RRR)-3' 88–95  
   121–125a  
   178–184  
   246–250  
Polypyrimidine tract 5'-YYYYY-3' 5–10  
   36–41  
Immunoglobulin heavy chain class switch repeat 5'-GAGCT-3' 141–145 DRB1*0328
   248–252 DRB1*0452
  5'-TGGGG-3' 145–149 DRB1*07
Deletion hotspot consensus 5'-TGAAGA-3' 37–42b  
  5'-TGRRKM-3' 145–150 DRB1*07
   250–255b  
Chi-like sequence 5'-GCTGGGG-3' 143–149 DRB1*07
  5'-CTGG-3' 144–147b DRB1*07
   167–170b DRB1*0705
   176–179  
Topoisomerase I consensus cleavage site 5'-CTY-3' 38–40  
   251–253 DRB1*0423, *0452
  5'-GTY-3' 4–6  
   31–33  
   47–49b  
   108–110b  
   114–116b  
   171–173b  
   183–185b  
   213–215b  
   231–233b  
DNA polymerase a pause site core sequence 5'-GAG-3' 51–53 DRB1*0439
   121–123  
   246–251 (2×)  
   268–270  
  5'-ACG-3' 2–4  
   115–117  
   116–118b  
Deletion hotspot 5'-YYYTG-3' 7–11  
   177–181b DRB1*0705
   187–191 DRB1*1374
  1. Only the motifs present in at least an (almost) entire allelic family are presented; some less common motifs are presented in the text. The ambiguity code symbols are: R = A/G, Y = C/T, K = G/T, M = A/C, S = G/C, W = A/T, N = A/C/G/T.
  2. amotif ± 1 bp
  3. b motif in non-coding strand corresponding to these bases in the coding strand.