From: Sequence features of HLA-DRB1 locus define putative basis for gene conversion and point mutations
Position | Sequence (underlined letters corresponding to motif in table 2) | Corresponding motif in Table 2 |
---|---|---|
4–8 | 5'-GTTTC-3' | Polypyrimidine tract |
30–32 | 5'-TGT-3' |  |
36–43 | 5'-TTCTTCA A-3' 5'-TTCTTC AA-3' | Deletion hotspot consensus sequence (5'-TGAAGA-3') in non-coding strand Polypyrimidine tract (5'-TTCTTC-3') |
47–49 | 5'-GAC-3' |  |
51–54 | 5'-GAGC-3' |  |
56–60 | 5'-GGTGC-3' |  |
107–119 | 5'-CGACAGCGACGTG-3' |  |
121–124 | 5'-GGGA-3' | Polypurine tract |
142–145 | 5'-AGCT-3' | Part of the immunoglobulin heavy chain class switch repeat (5'-GAGCT-3')a |
 | 5'-AGCT-3' | Part of the chi-like sequence (5'-GCT GGGG-3')a |
147–149 | 5'-GGG-3' | Part of deletion hotspot consensus sequence (5'-TGRRK M-3')a |
 | 5'-GGG-3' | Part of the chi-like sequence (5'-GCTGGGG-3')a |
167–174 | 5'-CTGGAACA-3' |  |
179–182 | 5'-GAAG-3' |  |
210–215 | 5'-GTGGAC-3' |  |
222–227 | 5'-TGCAGA-3' |  |
229–235 | 5'-ACAACTA-3' |  |
246–250 | 5'-GAGAG-3' | Polypurine trac |
248–250 | 5'-GAG-3' | Part of the immunoglobulin heavy chain class switch repeat (5'-GAG CT-3')a |
252–256 | 5'-TTCA C-3' | Deletion hotspot consensus sequence |
261–263 | 5'-CAG-3' |  |
267–269 | 5'-CGA-3' |  |