Trait-trait dynamic interaction: 2D-trait eQTL mapping for genetic variation study

BMC Genomics

Table 4 Co-expression between HAP4 and its six target genes are mediated by a locus in marker block 41.

Gene1	Gene2	LA score I	Corr(Gene1, Gene2)			LA
			Overall	RM	BY	score II
HAP4	ATP4	-0.264	0.38	0.60	0.10	0.321
HAP4	ATP5	-0.231	0.29	0.51	0.04	0.237
HAP4	ATP7	-0.216	0.25	0.49	0.01	0.292
HAP4	ATP14	-0.292	0.20	0.50	-0.16	0.367
HAP4	MEF2	-0.256	0.21	0.53	-0.10	0.381
HAP4	PPA2	-0.334	0.21	0.57	-0.19	0.322

For the column of LA score I, we use Z = marker profile of Marker block 41. We ask whether more extreme LA scores can be observed for all the six cases by chance. Using random permutation, we get 32 positive results from 5000 permutations, corresponding to a permutation p-value 0.0064. For the column of LA score II, we use Z = expression profile of TCM62. We ask whether more extreme LA scores can be observed for all the six cases by chance. Using random permutation, we get 10 positive results from 5000 permutations, corresponding to a permutation p-value 0.002.

ISSN: 1471-2164