Comparison of differential mRNA expression between Leishmania major and Leishmania infantum . Venn diagram comparing L. infantum and L. major genes significantly upregulated (> 1.7-fold, p < 0.05) in either log-phase promastigotes or intramacrophage amastigotes. The intersection of the Venn diagrams shows the number of genes that were common to both species. These common genes are listed in Table 2. The numbers within separate circles correspond to differentially expressed genes that are unique to each species. Species comparison was performed only on probes that had less than two mismatches when hybridized to either Leishmania species. Thus, ~7000 probes could be directly compared between the two organisms.