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Table 2 Differentially expressed genes common to Leishmania infantum and Leishmania major.

From: Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species

GO annotation (molecular function) Accession number (GeneDB) L. infantum Fold increase Accession number (GeneDB L. major Fold increase
Metabolic process
3-ketoacyl-coa thiolase LinJ23_V3.0860 2,1 a LmjF23.0690 3,3 a
hydrolase, alpha/beta fold family LinJ17_V3.1110 1,7 a LmjF17.1010 1,8 a
vacuolar ATP synthase subunit B LinJ28_V3.2610 1,8 a LmjF28.2430 1,7 a
succinyl-coA:3-ketoacid-coenzyme A transferase b LinJ33_V3.2470 1,8 c LmjF33.2340 2,1 a
hydrolase, alpha/beta fold family LinJ17_V3.1110 1,7 c LmjF17.1010 1,8 c
Carbohydrate metabolic process
acetyl-CoA synthetase LinJ23_V3.0880 2,0 a LmjF23.0710 4,5 a
aldose 1-epimerase LinJ35_V3.1000 1,8 a LmjF35.0980 2,4 a
enolase LinJ14_V3.1240 2,3 a LmjF14.1160 2,4 a
myo-inositol-1-phosphate synthetase LinJ14_V3.1450 2,4 c LmjF14.1360 4,7 c
Lipid metabolic process
3-oxo-5-alpha-steroid 4-dehydrogenase LinJ25_V3.1850 1,7 a LmjF25.1770 3,0 a
fatty acid elongase LinJ14_V3.0700 2,0 a LmjF14.0670 3,2 a
lathosterol oxidase LinJ23_V3.1560 1,9 a LmjF23.1300 3,6 a
phosphoglycan beta 1,3 galactosyltransferase LinJ02_V3.0140 1,8 a LmjF02.0160 3,8 a
phosphoglycan beta 1,3 galactosyltransferase d   22,0 c   2,4-11,8 c
hypothetical LinJ13_V3.0200 2,7 c LmjF13.0200 3,8 c
Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
adenylosuccinate synthetase LinJ13_V3.1090 1,8 a LmjF13.1190 2,0 a
  LinJ25_V3.1210    
  LinJ25_V3.2580   LmjF25.1170,  
ATPase beta subunit LinJ25_V3.2590 2,1 a LmjF25.1180 1,9 a
DNA metabolic process
3'-nucleotidase/nuclease LinJ12_V3.0350 2,0 a LmjF12.0400 3,9 a
3'-nucleotidase/nuclease precursor LinJ31_V3.2380 1,7 a LmjF31.2310 4,6 a
histone 1 LinJ33_V3.3390 2,6 a LmjF33.3240 1,9 a
3'-nucleotidase/nuclease LinJ31_V3.2370 2,0 c LmjF31.2300 1,7 c
double-strand-break repair protein rad21 LinJ05_V3.1090 3,0 c LmjF05.1090 1,9 c
RNA metabolic process
exosome complex exonuclease RRP45 LinJ22_V3.1430 3,1 c LmjF22.1580 1,8 c
RNA-binding protein 5 LinJ09_V3.0080 3,4 c LmjF09.0060 1,7 c
Amino acid and derivative metabolic process
glutamate dehydrogenase LinJ15_V3.1070 1,8 a LmjF15.1010 1,8 a
Protein metabolic process
HSP 70 LinJ32_V3.2050 2,0 a LmjF32.1940 1,9 a
Proteolysis
  LinJ14_V3.0910,    
calpain-like cysteine peptidase LinJ14_V3.0920 1,7 a LmjF14.0850 4,5 a
calpain-like cysteine peptidase LinJ20_V3.1320 2,0 a LmjF20.1280 2,1 a
calpain-like cysteine peptidase LinJ20_V3.1350 1,7 a LmjF20.1310 2,9 a
calpain-like cysteine peptidase LinJ27_V3.2490 1,8 a LmjF27.0510 2,8 a
calpain-like cysteine peptidase LinJ32_V3.1020 1,8 a LmjF32.0970 1,9 a
    LmjF01.0830,  
    LmjF02.0740,  
peptidyl-dipeptidase LinJ02_V3.0710 1,7 a LmjF27.2660 2,5 a
puromycin-sensitive aminopeptidase-like LinJ12_V3.0830 2,1 c LmjF12.1250 1,8 c
Protein modification process
protein kinase A catalytic subunit LinJ18_V3.1090 1,9 a LmjF18.1080 3,2 a
protein kinase A regulatory subunit LinJ13_V3.0160 2,5 a LmjF13.0160 2,1 a
protein kinase LinJ30_V3.1780 2,5 c LmjF30.1780 1,7 c
Electron transport
trypanothione synthetase LinJ23_V3.0500 1,7 c LmjF23.0460 1,8 c
Cellular component organization and biogenesis
dynein heavy chain LinJ13_V3.1390 1,7 a LmjF13.1650 2,1 a
dynein heavy chain LinJ26_V3.1000 1,9 a LmjF26.1020 1,7 a
dynein heavy chain LinJ28_V3.0650 1,8 a LmjF28.0610 2,0 a
dynein heavy chain (pseudogene) LinJ27_V3.2460 2,1 a LmjF27.2590 2,0 a
dynein light chain LinJ24_V3.1050 2,0 a LmjF24.1030 2,0 a
dynein-associated roadblock LinJ35_V3.1740 1,8 a LmjF35.1750 2,1 a
OSM3-like kinesin LinJ17_V3.0890 1,7 a LmjF17.0800 2,0 a
Cell motility
    LmjF39.1750,  
  LinJ29_V3.1880,   LmjF29.1760  
PFR 1D LinJ29_V3.1890 3,9 a LmjF29.1770 4,5 a
  LinJ16_V3.1510,   LmjF16.1425,  
PFR 2C LinJ16_V3.1520 3,7 a LmjF16.1430 5,3 a
paraflagellar rod component LinJ09_V3.1390 1,9 a LmjF09.1320 2,8 a
Cell communication
    LmjF09.0910,  
  LinJ09_V3.0970,   LmjF09.0920  
calmodulin LinJ09_V3.0980 2,0 a LmjF09.0930 2,8 a
calmodulin LinJ13_V3.1060 1,8 a LmjF13.1160 1,8 a
receptor-type adenylate cyclase a LinJ17_V3.0120 1,7 a LmjF17.0200 1,8 a
    LmjF17.0230,  
  LinJ17_V3.0140,   LmjF17.0235  
receptor-type adenylate cyclase b LinJ17_V3.0160 1,8 a LmjF17.0237 2,6 a
Transport
amino acid transporter aATP11 b LinJ31_V3.0370 2,4 c LmjF31.0350 4,7 a
phosphate-repressible phosphate permease LinJ03_V3.0480 1,7 c LmjF03.0500 2,0 c
Unclassified
oxidoreductase LinJ36_V3.4380 1,7 a LmjF36.4170 1,7 a
leucine rich repeat protein LinJ32_V3.3200 1,7 a LmjF32.3010 2,2 a
leucine rich repeat protein LinJ10_V3.0160 2,1 a LmjF10.0180 2,3 a
protein tyrosine phosphatase LinJ05_V3.0280 1,8 a LmjF05.0280 2,6 a
hypothetical LinJ01_V3.0640 2,4 a LmjF01.0620 2,3 a
hypothetical LinJ02_V3.0520 3,9 a LmjF02.0550 5,0 a
hypothetical LinJ07_V3.0040 2,0 a LmjF07.0030 1,8 a
hypothetical LinJ07_V3.0470 1,8 a LmjF07.0310 2,7 a
hypothetical LinJ09_V3.1620 2,1 a LmjF09.1530 1,8 a
hypothetical LinJ10_V3.1370 1,9 a LmjF10.1230 1,9 a
hypothetical LinJ11_V3.0620 2,0 a LmjF11.0610 2,1 a
hypothetical LinJ11_V3.1040 2,1 a LmjF11.1040 2,0 a
hypothetical LinJ17_V3.0970 2,0 a LmjF17.0870 3,6 a
hypothetical LinJ18_V3.1640 3,5 a LmjF18.1640 6,6 a
hypothetical LinJ19_V3.0520 4,5 a LmjF19.0520 5,9 a
hypothetical LinJ20_V3.0760 1,7 a LmjF20.0700 1,8 a
hypothetical LinJ21_V3.0440 1,8 a LmjF21.0380 2,5 a
hypothetical LinJ23_V3.1190 2,0 a LmjF23.1020 4,6 a
hypothetical LinJ24_V3.1630 4,1 a LmjF24.1560 4,1 a
hypothetical LinJ24_V3.2200 2,4 a LmjF24.2110 1,8 a
hypothetical LinJ26_V3.2400 2,1 a Lm jF26.2380 3,0 a
hypothetical LinJ27_V3.0720 1,9 a LmjF27.0870 1,7 a
hypothetical LinJ28_V3.1150 2,1 a LmjF28.1060 2,9 a
hypothetical LinJ29_V3.0360 1,7 a Lm jF29.0350 1,9 a
hypothetical LinJ29_V3.1090 2,4 a Lm jF29.1000 3,0 a
hypothetical LinJ29_V3.1190 2,0 a Lm jF29.1100 1,8 a
hypothetical LinJ29_V3.1260 2,5 a Lm jF29.1170 3,2 a
hypothetical LinJ29_V3.2940 2,5 a Lm jF29.2830 3,7 a
hypothetical LinJ30_V3.2870 4,4 a Lm jF30.2850 8,5 a
hypothetical LinJ31_V3.1220 2,7 a LmjF31.1200 2,0 a
hypothetical LinJ32_V3.0360 1,7 a Lm jF32.0350 2,0 a
hypothetical LinJ32_V3.0370 2,2 a Lm jF32.0360 2,2 a
hypothetical LinJ32_V3.1840 2,2 a Lm jF32.1760 3,0 a
hypothetical LinJ32_V3.2020 2,8 a Lm jF32.1910 2,4 a
hypothetical LinJ33_V3.0660 3,7 a Lm jF33.0610 5,4 a
hypothetical LinJ34_V3.1620 2,0 a Lm jF34.1520 4,0 a
hypothetical LinJ34_V3.2590 1,7 a LmjF34.2760 1,8 a
hypothetical LinJ34_V3.4230 1,9 a Lm jF34.4600 3,0 a
hypothetical LinJ35_V3.5310 2,4 a Lm jF35.5340 4,0 a
hypothetical LinJ36_V3.0800 2,4 a LmjF36.0740 1,8 a
hypothetical LinJ36_V3.3000 1,8 a Lm jF36.2850 2,0 a
hypothetical LinJ36_V3.3780 1,8 a Lm jF36.3620 6,7 a
hypothetical LinJ36_V3.4440 4,1 a Lm jF36.4230 5,7 a
hypothetical LinJ36_V3.5010 2,7 a Lm jF36.4780 3,2 a
hypothetical LinJ36_V3.5140 2,3 a LmjF36.4910 1,9 a
hypothetical LinJ36_V3.5210 1,8 a LmjF36.4980 2,5 a
hypothetical LinJ35_V3.3780 1,8 c LmjF35.3730 1,7 a
    LmjF 23.1050,  
  LinJ23_V3.1210,   LmjF 23.1080,  
SHERP b LinJ23_V3.1230 2,5 c LmjF23.1086 1,7 a
Amastins e   1.9–6.8 c   1.9–25.4 c
    LmjF 05.1230,  
    LmjF19.1650  
GIPL galf transferase LinJ32_V3.4140 2,8 c LmjF32.3990 2,0 c
hypothetical LinJ01_V3.0650 1,7 c LmjF01.0630 2,5 c
hypothetical LinJ06_V3.1030 2,1 c LmjF06.0995 1,8 c
hypothetical LinJ08_V3.0650 2,0 c Lm jF08.0640 4,8 c
hypothetical LinJ10_V3.1130 2,7 c LmjF10.1050 1,8 c
hypothetical LinJ12_V3.0440 1,9 c Lm jF12.0480 5,1 c
hypothetical LinJ16_V3.0100 1,9 c Lm jF16.0090 2,5 c
hypothetical LinJ24_V3.2320 2,7 c LmjF24.2230 1,7 c
hypothetical LinJ25_V3.2870 2,3 c LmjF35.2820 1,8 c
hypothetical LinJ26_V3.1440 1,8 c Lm jF26.1460 2,0 c
hypothetical LinJ27_V3.0770 20,8 c Lm jF27.0910 1,9 c
hypothetical LinJ27_V3.2320 2,5 c LmjF27.2370 1,8 c
hypothetical LinJ30_V3.0820 2,0 c LmjF30.0770 1,8 c
hypothetical LinJ30_V3.1000 7,1 c LmjF30.0940 2,7 c
hypothetical LinJ30_V3.2340 1,7 c Lm jF30.2330 2,4 c
hypothetical LinJ31_V3.1190 2,1 c Lm jF31.1170 2,7 c
hypothetical LinJ 31_V 3.2140 1,9 c LmjF 31.2090 2,0 c
hypothetical LinJ 32_V3.3600 1,9 c LmjF 32.3400 2,3 c
hypothetical LinJ 33_V3.1720 4,2 c Lm jF 33.1620 4,5 c
hypothetical LinJ 35_V3.5130 1,7 c Lm jF 35.5160 1,8 c
  1. a Genes differentially expressed in promastigotes.
  2. b Genes differentially expressed but not in the same life stage.
  3. c Genes differentially expressed in amastigotes.
  4. d The majority of the phosphoglycan 1,3 galactosyltransferase gene family members are differentially expressed in amastigotes. These genes are listed in Additional files 2 and 4.
  5. e The majority of the amastin gene family members are differentially expressed in amastigotes. These genes are listed in Additional files 2 and 4.