Figure 6

Schematic diagram of the network algorithm to estimate connectivity index ( C _i ) from the interactome. Filled circles represent the i^th gene (i = 1,2, ..., K), and filled diamonds the other genes reported in the literature to have one or more functional associations with the i^th gene. Broken arrows are associations that were not taken into the calculation due to the reverse direction along the connection path. L_i,jis the number of unique genes connecting to the i^th gene at the j^th step, C_i,jis the connectivity of the i^thgene at the j^th step, and C _i is the connectivity of the i^th gene, which is the limit of C_i,j.