Developing and applying a gene functional association network for anti-angiogenic kinase inhibitor activity assessment in an angiogenesis co-culture model

Table 2 Gene Ontology terms enriched with differentially expressed genes in NHDF cells of different passages

GO¹	GO Term	DEG²	FDR³
Biological Process	blood vessel development	64	0.00700
	vasculature development	64	0.00700
	actin filament organization	40	0.00850
	actin cytoskeleton organization and biogenesis	81	0.00850
	actin filament-based process	84	0.00850
	regulation of signal transduction	98	0.01020
	angiogenesis	56	0.01140
	blood vessel morphogenesis	60	0.01140
	cell morphogenesis	161	0.02020
Cellular Component	extracellular matrix	75	0.00200
	proteinaceous extracellular matrix	74	0.00200
	actin cytoskeleton	60	0.04800
	adherens junction	30	0.06140
	cell-matrix junction	25	0.06140
	cytoskeleton	132	0.06140
Molecular Function	protein binding	864	0.00820
	binding	1195	0.01740
	cytoskeletal protein binding	95	0.02380

1. Gene Ontology; 2. Differentially expressed genes; 3. False discovery rate.
Listed are GO categories identified through enrichment testing of the differentially expressed genes from NHDF cells using the DAVID functional annotation system as described in the methods section.

ISSN: 1471-2164