Developing and applying a gene functional association network for anti-angiogenic kinase inhibitor activity assessment in an angiogenesis co-culture model

Table 3 The most connected thirty molecules in the interactome

Rank	Gene	Connectivity	Percentage
1	TGFB1	397	2
2	TP53	301	4
3	IGF1	290	6
4	MAPK1	270	7
5	FGF2	261	9
6	PDGF	251	10
7	AKT1	248	12
8	SRC	243	13
9	JUN	242	15
10	AGT	231	16
11	SP1	230	17
12	IL6	220	18
13	IL1B	216	20
14	NGFB	207	21
15	VEGF	183	22
16	MYC	173	23
17	MAPK8	169	24
18	HGF	168	25
19	RAF1	162	26
20	MAPK3	156	27
21	CREB1	146	28
22	EP300	141	28
23	EGFR	138	29
24	CDKN1A	122	30
25	RAC1	117	31
26	STAT3	115	31
27	BCL2	109	32
28	PRL	108	33
29	PPARG	103	33
30	NR3C1	101	34

Genes within the regulation network or interactome were ranked by their connectivity in the network, i.e., the number of genes that they directly engaged with. Listed above are the top 30 genes with the highest connectivity. Gene symbols are those assigned by Human Gene Nomenclature Committee (HGNC).