Figure 1

Data used to detect mSNPs. Part of the genomic sequence of the OAS1 gene showing alternative acceptor site use at exon 7. The putative causative SNP (rs10774671), which occurs at the G site of the canonical acceptor dinucleotide, and an mSNP (rs2660), which was used to infer allele-specific splicing from EST data, are shown. Splice isoforms and mSNP alleles observed in three of a total of 27 cDNA libraries with ESTs that mapped to this region are also depicted. For each library the data are summarized in a two-by-two contingency table, with each ESTs cross-classified according to mRNA isoform and SNP allele.