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Table 1 The enriched GO terms for target genes of endo-siRNAs.

From: Functional characterization of endogenous siRNA target genes in Caenorhabditis elegans

All siRNAs with a putative target
Biological process n Per cent p-value
   embryonic development 534 23.9 3.6E-44
   multicellular organismal process 729 32.7 7.3E-42
   reproduction 397 17.8 2.0E-32
   larval development 321 14.4 4.3E-24
   growth 388 17.4 6.1E-24
   post-embryonic development 339 15.2 7.1E-24
   cell division 100 4.5 7.9E-23
   embryonic cleavage 68 3.0 9.4E-16
   sexual reproduction 170 7.6 2.1E-15
   reproductive process 185 8.3 1.2E-14
   Molecular function N Per cent p-value
   nucleotide binding 291 13.0 1.7E-23
   purine nucleotide binding 245 11.0 4.5E-16
   ribonucleotide binding 235 10.5 4.6E-16
   ATP binding 205 9.2 6.1E-15
   adenyl ribonucleotide binding 205 9.2 7.6E-15
   protein binding 398 17.8 9.7E-15
   RNA binding 83 3.7 8.6E-12
   nucleic acid binding 295 13.2 6.5E-11
   helicase activity 28 1.3 1.0E-5
   protein serine/threonine kinase activity 83 3.7 1.9E-5
22 nucleotides long siRNAs    
   Biological process N Per cent p-value
   multicellular organismal development 293 33.4 1.1E-21
   embryonic development ending in birth or egg hatching 221 25.2 2.7E-20
   reproduction 170 19.4 7.5E-16
   growth 161 18.4 1.1E-10
   cell division 44 5.0 1.4E-10
23 nucleotides long siRNAs    
   Biological process N Per cent p-value
   multicellular organismal development 87 25.4 1.6E-5
   reproduction 50 14.6 1.9E-4
   anatomical structure development 34 9.9 4.9E-4
   cell division 14 4.1 7.5E-4
   cell cycle process 13 3.8 1.2E-3
26 nucleotides long siRNAs    
   Biological process N Per cent p-value
   phosphate metabolic process 26 11.9 4.4E-09
   biopolymer modification 27 12.3 1.7E-07
   cellular protein metabolic process 32 14.6 1.1E-04
   cellular macromolecule metabolic process 32 14.6 2.0E-04
   biopolymer metabolic process 38 17.4 2.4E-04
  1. Target gene lists were submitted to DAVID 2.0 as described in methods. The 10 most significant GO categories are shown for all siRNAs with a putative target. The 5 most significant GO categories are presented for the siRNAs according to their length. The lists for siRNAs of all lengths are presented in Additional file 4.