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Table 1 The enriched GO terms for target genes of endo-siRNAs.

From: Functional characterization of endogenous siRNA target genes in Caenorhabditis elegans

All siRNAs with a putative target

Biological process

n

Per cent

p-value

   embryonic development

534

23.9

3.6E-44

   multicellular organismal process

729

32.7

7.3E-42

   reproduction

397

17.8

2.0E-32

   larval development

321

14.4

4.3E-24

   growth

388

17.4

6.1E-24

   post-embryonic development

339

15.2

7.1E-24

   cell division

100

4.5

7.9E-23

   embryonic cleavage

68

3.0

9.4E-16

   sexual reproduction

170

7.6

2.1E-15

   reproductive process

185

8.3

1.2E-14

   Molecular function

N

Per cent

p-value

   nucleotide binding

291

13.0

1.7E-23

   purine nucleotide binding

245

11.0

4.5E-16

   ribonucleotide binding

235

10.5

4.6E-16

   ATP binding

205

9.2

6.1E-15

   adenyl ribonucleotide binding

205

9.2

7.6E-15

   protein binding

398

17.8

9.7E-15

   RNA binding

83

3.7

8.6E-12

   nucleic acid binding

295

13.2

6.5E-11

   helicase activity

28

1.3

1.0E-5

   protein serine/threonine kinase activity

83

3.7

1.9E-5

22 nucleotides long siRNAs

   

   Biological process

N

Per cent

p-value

   multicellular organismal development

293

33.4

1.1E-21

   embryonic development ending in birth or egg hatching

221

25.2

2.7E-20

   reproduction

170

19.4

7.5E-16

   growth

161

18.4

1.1E-10

   cell division

44

5.0

1.4E-10

23 nucleotides long siRNAs

   

   Biological process

N

Per cent

p-value

   multicellular organismal development

87

25.4

1.6E-5

   reproduction

50

14.6

1.9E-4

   anatomical structure development

34

9.9

4.9E-4

   cell division

14

4.1

7.5E-4

   cell cycle process

13

3.8

1.2E-3

26 nucleotides long siRNAs

   

   Biological process

N

Per cent

p-value

   phosphate metabolic process

26

11.9

4.4E-09

   biopolymer modification

27

12.3

1.7E-07

   cellular protein metabolic process

32

14.6

1.1E-04

   cellular macromolecule metabolic process

32

14.6

2.0E-04

   biopolymer metabolic process

38

17.4

2.4E-04

  1. Target gene lists were submitted to DAVID 2.0 as described in methods. The 10 most significant GO categories are shown for all siRNAs with a putative target. The 5 most significant GO categories are presented for the siRNAs according to their length. The lists for siRNAs of all lengths are presented in Additional file 4.
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BMC Genomics

ISSN: 1471-2164

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