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Table 2 Summary of study factors with significant Hotelling-Lawley (H) and Variance Components (V) scores in each tissue-array set

From: Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories

 

Liver RAE230A

Liver RAE230 2.0

Liver RGU34A

Kidney RAE230A

Kidney RAE230 2.0

Kidney RGU34A

Gender

Ha Vb

-c

V

H V

V

d

Fasted

V

H V

V

-

  

Strain

V

H

 

-

 

H V

Organ Section

 

H

 

-

HV

-

Fixation

V

-

  

-

H V

RNA Amount

V

H

  

-

H

Lab

 

H

H

  

H

Dose Duration

 

H V

  

H

 

Vehicle

H

H

   

H

Sacrifice Method

V

H

 

-

  

Diet

 

H V

 

-

  

Study(Lab)

  

H

   

Route

  

V

 

-

 

Age

     

H

Dose Frequency

V

  

-

-

 

Scanner

 

-

V

-

-

 

Anesthetic

   

-

  
  1. aH: Large Hotelling-Lawley statistic (HLi > 35% of HLfull)
  2. bV: Large Variance Components statistic (Vi > Verror)
  3. c"-" Not tested (single factor level within tissue-array set)
  4. dBlank: Small effect for both H and V
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BMC Genomics

ISSN: 1471-2164

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