|
Disease Progression
|
Day(s) Post Infection
|
|---|
| |
0
|
1
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
|---|
|
Roughening of Fur
|
0
|
0
|
5
|
9
|
9
|
8
|
5
|
1
|
1
|
-
|
|
Hunched Posture/Lethargic/Shivering
|
0
|
0
|
0
|
0
|
9
|
8
|
5
|
1
|
1
|
-
|
|
Hind Limb Paralysis
|
0
|
0
|
0
|
0
|
1
|
8
|
5
|
1
|
1
|
-
|
|
Death
|
0
|
0
|
0
|
0
|
0
|
1
|
3
|
4
|
0
|
1
|
|
Total died/Total No.
|
0/9
|
0/9
|
0/9
|
0/9
|
0/9
|
1/9
|
4/9
|
8/9
|
8/9
|
9/9
|
|
% Mortality
|
0
|
0
|
0
|
0
|
0
|
11.1
|
44.4
|
88.8
|
88.8
|
100
|
|
MST (Day)
|
6.66
|
- Mice were infected with 1000 pfu of V3000 in left rear foot pad at day 0 and were monitored for the clinical symptoms of disease thereafter. All the animals exhibited hind limb paralysis, a hallmark of VEEV infection and succumbed to disease by day 9 post infection. Mortality was 100% with a mean survival time of 6.6 days.
