Venezuelan equine encephalitis virus infection causes modulation of inflammatory and immune response genes in mouse brain

Table 1 Progression of disease and mortality in VEEV infected mice.

Disease Progression	Day(s) Post Infection
	0	1	2	3	4	5	6	7	8	9
Roughening of Fur	0	0	5	9	9	8	5	1	1	-
Hunched Posture/Lethargic/Shivering	0	0	0	0	9	8	5	1	1	-
Hind Limb Paralysis	0	0	0	0	1	8	5	1	1	-
Death	0	0	0	0	0	1	3	4	0	1
Total died/Total No.	0/9	0/9	0/9	0/9	0/9	1/9	4/9	8/9	8/9	9/9
% Mortality	0	0	0	0	0	11.1	44.4	88.8	88.8	100
MST (Day)	6.66

Mice were infected with 1000 pfu of V3000 in left rear foot pad at day 0 and were monitored for the clinical symptoms of disease thereafter. All the animals exhibited hind limb paralysis, a hallmark of VEEV infection and succumbed to disease by day 9 post infection. Mortality was 100% with a mean survival time of 6.6 days.

ISSN: 1471-2164