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Table 3 Genes involved in virus response, inflammatory response and antigen presentation

From: Venezuelan equine encephalitis virus infection causes modulation of inflammatory and immune response genes in mouse brain

UniGene ID

Functional Grouping (Gene)

Upregulation (fold change) (Hours post infection)

  

24

48

72

96

 

Virus Response and Inflammation

    

Mm.136224

Interferon induced with helicase C domain 1 (Ifih1)

NE

3.59/-

5.21 ± 1.05

4.18 ± 0.31

Mm.3233

Interferon regulatory factor 7 (Irf7)

NE

NE

4.31 ± 1.51

2.01 ± 0.08

Mm.271275

Interferon, alpha-inducible protein 27 (Ifi27)

NE

NE

4.79 ± 0.67

6.62 ± 0.32

Mm.233471

2'-5' oligoadenylate synthetase 1B (Oas1b)

NE

1.89/-

5.12 ± 0.04

2.32 ± 0.08

Mm.867

Chemokine (C-C motif) ligand 12 (Ccl12)

5.03 ± 1.86

4.63/-

7.87 ± 0.54

4.70 ± 0.36

Mm.131723

Chemokine (C-X-C motif) ligand 11 (Cxcl11)

NE

8.76/-

17.02 ± 5.19

13.68 ± 5.51

Mm.877

Chemokine (C-X-C motif) ligand 10 (Cxcl10)

NE

7.49/-

15.45 ± 0.67

8.69 ± 0.37

Mm.284248

Chemokine (C-C motif) ligand 5 (Ccl5)

NE

NE

4.27 ± 1.27

3.56 ± 0.66

Mm.1282

Chemokine (C-C motif) ligand 3 (Ccl3)

NE

NE

2.26/1.83

2.05 ± 0.21

Mm.10116

Chemokine (C-X-C motif) ligand 13 (Cxcl13)

NE

NE

2.06 ± 0.41

1.73/-

Mm.766

Chemokine (C-X-C motif) ligand 9 (Cxcl9)

NE

NE

3.99 ± 1.62

1.85 ± 0.14

Mm.22673

Fc receptor, IgE, high affinity I, gamma polypeptide (Fcer1g)

NE

NE

3.66 ± 0.29

3.38 ± 0.63

Mm.5419

Interleukin 17 (Il17)

NE

NE

NE

2.06 ± 0.33

Mm.2326

Macrophage migration inhibitory factor (Mif)

NE

1.08 ± 0.17

2.25 ± 0.53

2.06 ± 0.07

Mm.24163

PYD and CARD domain containing (Pycard)

NE

NE

1.81 ± 0.165

1.52 ± 0.31

Mm.200608

Clusterin (Clu)

NE

1.74 ± 0.13

4.03 ± 1.54

2.45 ± 0.37

Mm.283714

Sialophorin (Spn)

1.93 ± 0.14

2.50 ± 0.19

2.87 ± 1.63

2.25 ± 0.24

 

Antigen Presentation

    

Mm.209294

Adaptor-related protein complex 3, delta 1 subunit (Ap3d1)

1.33 ± 0.83

NE

2.17 ± 0.35

1.69 ± 0.01

Mm.163

Beta-2 microglobulin (B2m)

NE

NE

10.39 ± 0.32

6.07 ± 0.25

Mm.1894

CD1d1 antigen (Cd1d1)

NE

NE

NE

1.56 ± 0.01

Mm.22673

Fc receptor, IgE, high affinity I, gamma polypeptide (Fcer1g)

NE

NE

3.66 ± 0.29

3.38 ± 0.63

Mm.33263

Histocompatibility 2, D region locus 1 (H2-D1)

NE

NE

4.88 ± 0.12

9.04 ± 1.15

Mm.387141

Histocompatibility 2, D region locus 4 (H2-D4)

NE

NE

8.92 ± 7.66

9.42 ± 1.34

Mm.35016

Histocompatibility 2, T region locus 23 (H2-T23)

NE

NE

4.72 ± 0.89

3.15 ± 0.83

Mm.296901

Histocompatibility 2, Q region locus 7 (H2-Q7)

4.55 ± 2.49

4.58/-

10.22 ± 4.92

9.50 ± 0.76

Mm.296901

Histocompatibility 2, Q region locus 8 (H2-Q8)

NE

NE

4.45 ± 0.48

NE

  1. Genes that are involved in the virus response and immune response were upregulated at 72 and 96 hr post infection concomitant with the virus appearance in the brain. Several inflammatory response and antigen presentation genes were upregulated and their expression increased with the progression of the disease. Values are fold changes in the gene expression in test samples over saline controls. Values are expressed as mean ± SEM. NE indicates not expressed or expression was lower than 1 fold (and/or did not meet the cut off criteria of 99% confidence interval, 150 minimum intensity or 30 μm spot size) NE indicates not expressed and '-' indicates not expressed in biological replicates.