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Table 4 Genes involved in apoptotic response in VEEV infected mice brain.

From: Venezuelan equine encephalitis virus infection causes modulation of inflammatory and immune response genes in mouse brain

UniGene ID Functional Grouping (Gene) Upregulation (fold change) (Hours post infection)
   24 48 72 96
  Apoptosis     
Mm.3336 RIKEN cDNA 1110007C09 gene (1110007C09Rik) 2.66 ± 1.63 3.68 ± 1.14 6.81 ± 4.35 5.22 ± 0.66
Mm.277585 amyloid beta (A4) precursor protein (App) 2.50 ± 0.48 2.54 ± 0.59 4.05 ± 1.20 2.87 ± 0.42
Mm.84073 Bcl2-associated athanogene 3 (Bag3) 2.63 ± 0.59 3.30 ± 0.43 4.61 ± 2.37 4.23 ± 0.18
Mm.29820 BCL2/adenovirus E1B 19kDa-interacting protein 3-like (Bnip3l) 1.96 ± 0.11 2.52 ± 0.04 3.88 ± 2.19 3.07 ± 0.14
Mm.290908 baculoviral IAP repeat-containing 6 (Birc6), mRNA. 1.94 ± 0.33 2.15 ± 0.22 2.54 ± 0.93 2.18 ± 0.04
Mm.283714 sialophorin (Spn), mRNA. 1.99 ± 0.14 2.50 ± 0.19 2.87 ± 1.63 2.25 ± 0.24
Mm.2381 amyloid beta (A4) precursor-like protein 1 (Aplp1), NE 1.90 ± 0.06 3.70 ± 1.15 2.27 ± 0.14
Mm.200608 Clusterin (Clu) NE 1.74 ± 0.13 4.03 ± 1.54 2.45 ± 0.37
Mm.136224 interferon induced with helicase C domain 1 (Ifih1) NE 3.59/- 5.21 ± 1.05 4.18 ± 0.31
Mm.4266 integral membrane protein 2B (Itm2b) NE 1.55 ± 0.20 2.43 ± 0.95 2.46 ± 0.54
Mm.2326 macrophage migration inhibitory factor (Mif) NE 1.08 ± 0.17 2.25 ± 0.53 2.06 ± 0.07
Mm.277518 Monocyte to macrophage differentiation-associated (Mmd) NE 0.59 ± 0.04 2.33 ± 0.45 1.64 ± 0.18
Mm.347546 Inositol 1,3,4-triphosphate 5/6 kinase NE 1.94 ± 0.02 0.95 ± 0.05 1.83 ± 0.02
Mm.285322 mitochondrial carrier homolog 1 (C. elegans) (Mtch1) NE 0.95 ± 0.01 2.08 ± 0.35 1.77 ± 0.23
Mm.687 Ras homolog gene family, member B (Rhob) NE 1.17 ± 0.03 2.48 ± 0.87 1.59 ± 0.15
Mm.379457 Valosin containing protein (Vcp) NE 1.68 ± 0.15 2.04 ± 0.77 1.80 ± 0.17
Mm.6826 Apoptosis-associated tyrosine kinase (Aatk) NE NE 1.65 ± 0.07 1.20 ± 0.43
Mm.223689 Bifunctional apoptosis regulator (Bfar) NE NE 1.83 ± 0.58 1.70 ± 0.08
Mm.130832 caspase recruitment domain family, member 14 (Card14) NE NE 3.23 ± 1.52 2.69 ± 0.08
Mm.29028 Death associated protein 3 (Dap3) NE NE 1.87 ± 0.14 0.96 ± 0.03
Mm.280594 Death effector domain-containing DNA binding protein 2 (Dedd2) NE NE 1.79 ± 0.66 1.92 ± 0.09
Mm.379461 eukaryotic translation initiation factor 5A (Eif5a) NE NE 2.61 ± 0.49 1.92 ± 0.14
Mm.342392 engulfment and cell motility 1, ced-12 homolog (C. elegans) (Elmo1), transcript variant 2 NE NE 1.74 ± 0.21 1.41 ± 0.08
Mm.39760 Fas apoptotic inhibitory molecule 2 (Faim2) NE NE 2.85 ± 1.23 2.44 ± 0.12
Mm.281298 growth arrest and DNA-damage-inducible 45 gamma (Gadd45g) NE NE 3.16 ± 0.21 2.12 ± 0.05
Mm.15510 granzyme A (Gzma) NE NE 1.27 ± 0.41 1.94 ± 0.26
Mm.2720 Mitogen activated protein kinase 8 interacting protein 1 (Mapk8ip1) NE NE 2.25 ± 0.75 1.16 ± 0.19
Mm.1639 Myeloid cell leukemia sequence 1 (Mcl1) NE NE 1.83 ± 0.18 1.56 ± 0.09
Mm.204876 nucleolar protein 3 (apoptosis repressor with CARD domain) (Nol3) NE NE 2.02 ± 0.52 1.84 ± 0.09
Mm.24163 PYD and CARD domain containing (Pycard) NE NE 1.82 ± 0.17 1.38 ± 0.18
Mm.276325 superoxide dismutase 1, soluble (Sod1) NE NE 1.74 ± 0.22 1.54 ± 0.24
Mm.200792 tumor necrosis factor receptor superfamily, member 21 (Tnfrsf21) NE NE 2.37 ± 0.84 1.40 ± 0.17
Mm.1894 CD1d1 antigen (Cd1d1) NE NE NE 1.56 ± 0.01
Mm.217764 phosphoglucomutase 2 (Pgm2)/Itgb3bp NE NE NE 1.63 ± 0.11
Mm.312628 Serine (or cysteine) proteinase inhibitor, clade A, member 3G (Serpina3g) NE NE NE 2.83 ± 0.18
Mm.218473 tumor differentially expressed 1 (Tde1)/Serinc3 NE NE NE 1.94 ± 0.01
Mm.338613 forkhead box O3a (Foxo3a) 1.92 ± 0.17 NE 2.26 ± 1.08 1.57 ± 0.03
Mm.22216 TSC22 domain family 3 (Tcs22d3) NE 1.63 ± 0.20 NE NE
Mm.1360 growth arrest and DNA-damage-inducible 45 beta (Gadd45b) NE 2.00 ± 0.33 NE 1.85 ± 0.03
Mm.329277 ubiquitin specific peptidase 14 (Usp14)/Thoc1 NE 1.90 ± 0.21 NE 2.02 ± 0.18
Mm.347406 CCAAT/enhancer binding protein (C/EBP), beta (Cebpb) NE NE 2.01 ± 0.17 NE
Mm.150 Fc receptor, IgG, high affinity 1(Fcgr1) NE NE 2.26 ± 0.26 NE
Mm.292100 fibrinogen-like protein 2 (Fgl2) NE NE 1.90 ± 0.27 NE
Mm.368515 myc-like oncogene, s-myc protein (Mycs) NE NE 3.11 ± 0.05 NE
  1. Genes that are modulated in the apoptotic response were upregulated at 72 and 96 hr post infection concomitant with the virus appearance in the brain. Values are fold changes in the gene expression in test samples over saline controls. Values are expressed as mean ± SEM. NE indicates not expressed or expression was lower than 1 fold (and/or didn't meet the cut off criteria of 99% confidence interval, 150 minimum intensity or 30 μm spot size) and (-) indicates not expressed in biological replicates.
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BMC Genomics

ISSN: 1471-2164

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