Evolutional conservation of critical residues in Jmjd6 (stereoview). (A) Ribbon presentation of the predicted Jmjd6 structure is coloured based on the sequence homology observed in 54 Jmjd6 homologous proteins (Fig. 5). (B) Annotation of the sequence identity onto the catalytic domain demonstrated the conservation of the critical residues within the active site of the Jmjd6-Fe(II)-2OG complex. Residues were shaded according to the heat map with dark red representing total conservation of residues (100% sequence identity across 54 analysed species), and blue colour representing 50% sequence identity.