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Table 4 Genes in liver changed in two or more vegetable oil diets compared to salmon fed fish oil

From: Functional genomics reveals increases in cholesterol biosynthetic genes and highly unsaturated fatty acid biosynthesis after dietary substitution of fish oil with vegetable oils in Atlantic salmon (Salmo salar)

PROCESS

ACC. NO.

LO

RO

SO

EST-BLASTX OR EST-TC-BLASTX

HUFA BIOSYNTHESIS

DW588445

4.131

6.1

3.529

(Q9DEX7) Delta-5/delta-6 fatty acid desaturase

 

EG354827

3.814

3.864

0.685

(AAL82631) Salmon delta-5 fatty acyl desaturase, TC51151

 

EG647320

4.286

3.37

1.909

(Q9DEX7) Delta-5/delta-6 fatty acid desaturase

 

AAL82631

5.624

11.29

8.027

(Q9DEX7) Delta-5/delta-6 fatty acid desaturase

 

AAL82631

1.84

3.657

2.932

(Q9DEX7) Delta-5/delta-6 fatty acid desaturase

 

AAR21624

2.564

4.248

2.688

(Q9DEX7) Delta-5/delta-6 fatty acid desaturase

CHOLESTEROL AND ISOPRENOID BOSYNTHESIS

CK875291

13.61

12.23

13.86

(O35760) Isopentenyl-diphosphate delta-isomerase 1

 

CO471940

6.282

8.078

6.958

(Q4R4W5) Isopentenyl-diphosphate delta-isomerase 1

 

EG647637

14.11

2.921

20.59

(P52019) squalene epoxidase

 

CK874989

4.679

4.488

3.376

(O88822) Lathosterol oxidase

 

CK881623

1.132

0.762

0.764

(O42563) Cytochrome P450 3A27

LIPID METABOLISM AND TRANSPORT

NAN

1.494

1.881

1.613

(CAA57449) apolipoprotein B [Salmo salar], TC40920

 

AM042514

1.085

1.84

1.618

(Q96BZ4) PLD4 phospholipase D family, member 4, TC47857

 

DW589827

1.403

0.968

1.27

(P59837) Retinol dehydrogenase 12

 

BF228485

0.841

0.752

1.228

(Q9R182) Angiopoietin-related protein 3

 

NAN.

0.489

0.709

0.652

(Q9BYV7) BCDO2 Beta-carotene dioxygenase 2

 

AJ416951

0.541

0.696

0.799

(O88275) Peroxisome proliferator-activated receptor gamma

 

AM402843

0.362

0.67

0.441

(Q5TZ29) Novel protein similar to vertebrate apolipoprotein B

CARBOHYDRATE METABOLISM

CK880626

1.093

1.816

2.013

(P05370) G6PD Glucose-6-phosphate 1-dehydrogenase

 

AM083390

2.685

1.291

1.873

(Q5MIB6) Glycogen phosphorylase

 

NAN

2.316

1.609

1.256

(Q04760) GLO1 glyoxalase 1, TC39739

 

EG355381

0.47

0.659

0.7

(P15121) AKR1B1 aldo-keto reductase 1B1, TC40780

MITOCHONDRIAL FUNCTION

DW589236

8.96

2.524

1.84

(Q96EL2) MRPS24 mitochondrial ribosomal protein S24, TC34551

 

CK891719

3.013

2.495

2.212

(Q99595) Mitochondrial import inner membrane translocase Tim17 A

 

NAN

2.067

1.455

1.582

(Q9EQ20) aldh6a1 aldehyde dehydrogenase 6A1, TC37457

 

CK881059

0.97

0.515

0.587

(Q9H2U2) Inorganic pyrophosphatase 2, mitochondrial

 

EG649042

2.754

0.644

0.763

(P16036) Phosphate carrier protein, mitochondrial

PROTEIN PROCESSING AND TURNOVER

CK898137

2.407

1.258

1.377

(Q5ZIJ9) Ubiquitin ligase protein MIB2

 

CK878932

2.384

1.532

1.599

(P03974) Transitional endoplasmic reticulum ATPase

 

BM414061

5.083

5.299

5.287

(P97571) Calpain-1 catalytic subunit

 

CK893924

1.906

1.819

2.368

(Q99614) Tetratricopeptide repeat protein 1

 

DW591059

1.6

1.198

1.72

(ABQ57500) small heat shock protein HSPB9, TC57595

 

AM397488

0.357

0.941

0.517

(P45878) FK506-binding protein 2, TC38192

RNA PROCESSING

CK888026

1.133

1.293

1.791

(P09651) heterogeneous nuclear ribonucleoprotein A1, TC61954

 

CK892099

2.289

1.389

1.697

(P28048) La ribonucleoprotein A

 

DW588498

1.629

1.995

2.155

(Q9D198) syf2 SYF2 homolog, RNA splicing factor, TC34249

 

CK891976

1.222

1.093

1.373

(Q6PDM2) sfrs1 splicing factor, arginine/serine-rich 1, DY729372

 

DW589408

0.538

0.625

0.56

(Q9D0E1) heterogeneous nuclear ribonucleoprotein M, TC35947

 

CK884048

1.354

0.792

0.874

(P62317) Small nuclear ribonucleoprotein Sm D2

 

AJ425602

0.526

0.481

0.578

(Q5RF83) Cold-inducible RNA-binding protein

SIGNAL TRANSDUCTION

CK898218

2.04

1.571

1.642

(Q6PH57) Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta1

 

CK881679

2.84

1.823

2.093

(Q8JGT0) Casein kinase I alpha, TC40170

 

NAN

0.531

0.637

0.812

(Q8BXH3) gucy1b2 guanylate cyclase 1, soluble, beta 2, TC44944

 

CK879754

0.333

0.627

0.428

(Q14511) Enhancer of filamentation 1

 

CK877929

0.877

0.528

0.416

(Q2M5E4) RGS21 regulator of G-protein signaling 21, TC38138

 

CK884662

0.258

0.521

0.539

(P62142) Serine/threonine protein phosphatase PP1b catalytic

 

AM049833

0.603

0.862

0.689

(P62155) Calmodulin

 

BF228513

0.402

0.506

0.682

(Q8CFJ8) par-6 partitioning defective 6 homolog gamma, BF228513

TRANSCRIPTION

CN181085

1.588

1.189

1.597

(Q8BQ46) TAF15 RNA polymerase II, TC53593

 

EG648659

1.637

1.396

1.09

(Q6GPQ6) Endothelial differentiation-related factor 1 homolog

 

AM402809

1.363

1.469

1.242

(Q8BG15) ctdspl2 CTD small phosphatase like 2

 

CK898087

0.698

0.627

0.699

(Q9ERU2) Zinc finger protein 22

TRANSLATION

DW588363

1.032

1.227

1.414

(P17508) Elongation factor 1-alpha, oocyte form

 

EG648663

1.305

1.076

1.433

(Q9WV70) Nucleolar complex protein 2 homolog

 

NAN

1.974

1.225

1.812

(P18077) RPL35a ribosomal protein L35a, TC60182

 

EG647766

0.695

0.74

0.933

(P47826) 60S acidic ribosomal protein P0

 

CK886497

0.559

0.688

0.854

(P57776) Elongation factor 1-delta

EXTRACELLULAR MATRIX

CK877333

1.554

2.258

2.234

(Q98967) Cystatin

 

CK876354

0.869

0.671

0.631

(Q5D0F2) serine protease inhibitor, Kunitz type, 2, TC52802

 

AM042526

0.534

0.888

0.45

(P48307) TFPI2 tissue factor pathway inhibitor 2, TC51552

 

CK885060

0.386

0.419

0.476

(BAB55662) collagen a3(I), TC58897

 

AJ424854

0.432

0.483

0.776

(O93486) Alpha 3 type I collagen, TC43437

 

AJ425530

0.191

0.466

0.554

(Q9JM06) EGF- fibulin-like extracellular matrix protein 2, TC48959

IMMUNE FUNCTION

AM042172

1.456

0.444

0.472

(AAW66975) Ig mu heavy chain secretory form, TC58483

 

AM397498

0.075

0.667

0.446

(P08603) Complement factor H

ION TRANSPORT

AM402718

0.464

0.561

1.19

(Q9NYB5) solute carrier organic anion transporter 1C1, TC47786

 

CK885259

0.484

0.625

0.746

(Q9YH26) Sodium/potassium-transporting ATPase alpha-1 chain

 

AM402711

0.225

0.743

0.369

(Q28677) Solute carrier family 12 member 4

APOPTOSIS

CK879455

0.432

0.616

0.587

(O18998) Deoxyribonuclease-1

GROWTH AND PROLIFERATION

EG649002

1.157

1.746

1.278

(Q5R5D0) Cyclin-G1

 

CK876621

0.74

1.594

1.492

(Q80UU6) ogfr opioid growth factor receptor, TC55122

CYTOSKELETON

EG647322

4.417

4.16

2.259

(P49006) MARCKS-like 1, TC40754

 

DW588815

0.518

0.609

0.831

(P68372) Tubulin beta-? Chain

LYSOSOMAL

AM042088

0.598

0.579

0.583

(Q90744) Alpha-N-acetylgalactosaminidase

AA BIOSYNTH

CK890942

0.545

0.671

0.727

(A6H5Y3) mtr methionine synthase, TC52579

MUSCLE

DW591140

1.938

1.327

1.268

(P06741) MYL1 myosin, light chain 1, TC60893

RESPIRATION

EG648831

0.467

0.426

0.386

(P02142) Hemoglobin beta-1 subunit

UNKNOWN FUNCTION

EG647376

0.26

1.808

1.739

(XP_691559) hypothetical protein [Danio rerio], TC35542

 

NAN

0.93

1.98

1.353

(XP_001340266) hypothetical protein [Danio rerio], TC45154

 

AM042055

1.284

1.242

1.75

(Q6I9Y2) THOC7 THO complex 7 homolog, TC54560

 

AM402609

2.644

2.732

1.84

(Q56TU0) Type-4 ice-structuring protein precursor, TC59473

 

CK898312

1.492

1.959

2.192

(XP_692475) similar to CG6282-PA, isoform A, TC34514

 

CK897369

0.705

0.732

0.677

(Q5JVS0) HABP4 hyaluronan binding protein 4, TC34600

 

CK881591

0.288

0.295

0.408

(XP_001338932) hypothetical protein [Danio rerio], TC55348

 

BM414217

0.655

0.969

0.709

(XP_708731) hypothetical protein isoform 2, TC55763

TRANSPOSON

EG647536

0.993

1.841

1.305

(XP_001341934) similar to ReO_6, retrotransposon, TC63376

 

EG647893

0.318

0.428

0.423

(AAW27349) SJCHGC04625 protein, retrotransposon, TC46087

 

BM414246

0.907

0.525

0.54

(ABV31711) transposase, TC43560

 

CK879027

0.76

0.985

0.683

(Q04202) Transposable element Tcb2 transposase

  1. Numbers indicate expression ratio and a significant change (VO:FO; T-test, p ≤ 0.05) is indicated by bold type. LO, linseed oil; SO, soyabean oil; RO, rapeseed oil. Accession numbers of array features are provided. TC numbers are also provided, as described in text.
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BMC Genomics

ISSN: 1471-2164

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