Table 1 Functional clustering based on Gene Ontology
(A) Varroa | |||
|---|---|---|---|
| Â | P value | Up-regulated | Down-regulated |
Biological process (unknown) | Â | 6 (9) | 10 (6) |
cell organization and biogenesis | 0.000229 | 2 | 3 |
protein metabolism | 0.004808 | 4 | 5 |
cellular metabolism | 0.008242 | 4 | 6 |
protein modification | 0.035714 | 2 | 1 |
Molecular function (unknown) | Â | 5 (9) | 9 (8) |
transferase activity | 0.021978 | 3 | 0 |
catalytic activity | 0.041958 | 3 | 3 |
(B) Bee phenotype | |||
| Â | P value | Up-regulated | Down-regulated |
Biological process (unknown) | Â | 24 (20) | 24 (31) |
regulation of physiological process | 3.279e-08 | 3 | 6 |
regulation of transcription | 2.650e-09 | 3 | 5 |
Axonogenesis | 5.139e-06 | 0 | 4 |
cell division | 0.000231 | 0 | 3 |
Localization | 1.450e-05 | 7 | 2 |
axon guidance | 5.782e-05 | 0 | 3 |
Phosphorylation | 7.709e-05 | 1 | 3 |
cell organization and biogenesis | 0.000155 | 5 | 2 |
nervous system development | 7.359e-05 | 1 | 4 |
protein modification | 0.000360 | 3 | 1 |
Molecular function (unknown) | Â | 20 (24) | 26 (29) |
ATPase activity | 5.428e-05 | 2 | 1 |
nucleic acid binding | 3.480e-07 | 4 | 5 |
methyltransferase activity | 5.428e-05 | 1 | 2 |
pyrophosphatase activity | 4.720e-06 | 3 | 1 |
ion transporter activity | 5.428e-05 | 2 | 1 |
ubiquitin-protein ligase activity | 5.428e-05 | 2 | 1 |
kinase activity | 0.001086 | 2 | 1 |
catalytic activity | 2.904e-06 | 6 | 8 |
transmembrane receptor protein kinase activity | 5.428e-05 | 0 | 3 |
cytoskeletal protein binding | 0.000543 | 0 | 3 |
transferase activity | 1.339e-09 | 3 | 7 |
ion binding | 1.101e-05 | 2 | 2 |
signal transducer activity | 0.002336 | 0 | 4 |