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Table 3 Panther classification of biological processes and molecular functions significantly enriched in the set of 57 genes

From: Microarray analysis identifies a common set of cellular genes modulated by different HCV replicon clones

 

Observed Genes•

Expected Genes••

p-value•••

p-value with Bonferroni

correction

BIOLOGICAL PROCESSES

    

Nucleoside, nucleotide and nucleic acid

metabolism

14

7.62

1.63E-02

 

   Chromatin packaging and remodeling

6

0.54

1.75E-05

2.54E-03

   Chromosome segregation

2

0.28

3.14E-02

 

   Other mRNA transcription

1

0.05

4.68E-02

 

Intracellular protein traffic

6

2.3

2.70E-02

 

Molecular Functions

    

Nucleic acid binding

16

6.5

4.82E-04

1.40E-02

   Histone

6

0.2

5.21E-08

8.38E-06

   Ribosomal protein

5

1.06

4.19E-03

 

Etracellular matrix

5

0.88

1.85E-03

 

   Extracellular matrix glycoprotein

3

0.25

2.14E-03

 
  1. • Number of genes, in the dataset of 57 genes, that map to the indicated Panther classification categories.
  2. •• Expected number of genes in the dataset of 57, based on the NCBI reference list of human genome.
  3. ••• p-value as determined by the binomial statistic. A cutoff of 0.05 has been applied.
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BMC Genomics

ISSN: 1471-2164

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