From: Topoisomerase II inhibition involves characteristic chromosomal expression patterns
Window sizes analyzed [kbp] | Expected number of genes (100 randomized gene lists) | Standard deviation | Observed number of regulated genes | Significance (p-value) | |
---|---|---|---|---|---|
Aroclor (599) | 0–50 | 15.07 | 3.23 | 34 | 0.00000857 |
50–100 | 13.70 | 3.97 | 19 | 0.03657915 | |
100–200 | 24.62 | 4.60 | 25 | 0.08103966 | |
Trovafloxacin (1530) | 0–50 | 84.51 | 9.38 | 92 | 0.03045474 |
50–100 | 77.16 | 7.71 | 110 | 0.00005667 | |
100–200 | 127.52 | 9.30 | 143 | 0.01301018 | |
Doxorubicin (580) | 0–50 | 13.33 | 3.61 | 21 | 0.01286883 |
50–100 | 13.46 | 3.59 | 25 | 0.00140735 | |
100–200 | 23.73 | 4.83 | 23 | 0.08357927 | |
Etoposide (704) | 0–50 | 18.89 | 4.22 | 43 | 0.00024071 |
50–100 | 18.50 | 4.44 | 46 | 0.00336279 | |
100–200 | 34.56 | 4.78 | 81 | 0.00065127 | |
c-myc (899) | 0–50 | 30.82 | 5.36 | 23 | 0.02745216 |
50–100 | 29.27 | 5.67 | 29 | 0.07500742 | |
100–200 | 52.18 | 7.53 | 60 | 0.02919296 |