Skip to main content

Table 1 Number of genes found in different window sizes.

From: Topoisomerase II inhibition involves characteristic chromosomal expression patterns

  Window sizes analyzed [kbp] Expected number of genes (100 randomized gene lists) Standard deviation Observed number of regulated genes Significance (p-value)
Aroclor (599) 0–50 15.07 3.23 34 0.00000857
  50–100 13.70 3.97 19 0.03657915
  100–200 24.62 4.60 25 0.08103966
Trovafloxacin (1530) 0–50 84.51 9.38 92 0.03045474
  50–100 77.16 7.71 110 0.00005667
  100–200 127.52 9.30 143 0.01301018
Doxorubicin (580) 0–50 13.33 3.61 21 0.01286883
  50–100 13.46 3.59 25 0.00140735
  100–200 23.73 4.83 23 0.08357927
Etoposide (704) 0–50 18.89 4.22 43 0.00024071
  50–100 18.50 4.44 46 0.00336279
  100–200 34.56 4.78 81 0.00065127
c-myc (899) 0–50 30.82 5.36 23 0.02745216
  50–100 29.27 5.67 29 0.07500742
  100–200 52.18 7.53 60 0.02919296
  1. Comparison of the gene lists resulting from treatment with different topoisomerase II inhibitors or from overexpression of c-myc with the mean of 100 randomized gene lists. For each window size, the expected number of genes is shown along with the observed number of genes. The expected numbers of genes result from the mean of 100 randomized gene lists comprising the same number of genes as the respective regulated gene list. Furthermore, the p-value is shown for obtaining such a result by chance using the binominal distribution. Whenever the difference between the expected number of genes and the observed number of regulated genes is significant, the corresponding values are marked bold (expected number < observed number) or italic (expected number > observed number).