Figure 3

Occurrence of T-boxes in relation with different transporter families. The figure displays a NJ-tree of the LIVCS-family transporters of the Firmicutes (left) and partial trees related to the APC-, MFS- and NSS-family transporters. It appears T-boxes are only associated with very few proteins of these families and the association appears to be very species-specific. Bootstrap values are given for those clusters that contain T-box regulated systems (indicated in black). Those systems that are controlled by a T-box are colored. For the LIVCS-family the sequences of the experimentally studied transporters from Pseudomonas aeruginosa (BraZ [49]), Corynebacterium glutamicum (BrnQ [48]) and Lactobacillus delbrueckii (BrnQ [43]) were included in the analysis. For the APC-family all B. subtilis sequences were included together with the orthologous clusters containing T-box regulated systems. For the MFS- and NSS-family only the orthologous clusters containing T-box regulated systems are shown. In the case of the MFS-family the asterisk indicates that the upstream sequence of these systems contains a box that seems to be degenerated.