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Table 1 Genes induced at least 3 fold 2 h after X-ray treatment

From: Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family

name

X-ray 2 h

qRT-PCR

gamma-ray 2 h

gamma-ray 6 h

annotation

F49F1.6

155.32

134.9 ± 43.7

127.38

70.86

ShK domain-like, Secreted surface protein

K08D8.5

10.03

 

6.34

5.98

CUB-like domain, nematode specific

dod-22

9.90

61.4 ± 33.1

22.35

6.98

CUB-like domain/downstream of daf-16 , nematode specific

K08D8.4

9.45

 

5.84

1.11

CUB-like domain, nematode specific

clec-68

9.42

 

13.57

8.24

C-type lectin

clec-67

9.06

 

13.12

8.12

C-type lectin

dod-21

8.91

 

15.28

14.07

CUB-like domain/downstream of daf-16 , nematode specific

cdr-4

8.72

 

7.52

2.34

Glutathione S-transferase

C17H12.8

7.89

 

6.14

4.73

CUB-like domain, nematode specific

cdr-2

7.68

 

7.00

1.53

Glutathione S-transferase

Y41C4A.11

7.47

 

7.53

7.70

coatomer protein complex subunit beta

T24B8.5

7.34

 

4.03

4.13

ShK domain-like

F35E12.8

7.18

 

7.27

2.01

CUB-like domain, nematode specific

C49G7.7

6.93

 

5.70

1.03

CUB-like domain, nematode specific

K11H12.4

5.94

 

5.14

2.71

DUF274, nematode specific

Cyp-13A5

5.93

 

2.09

1.01

cytochrome P450

C31A11.5

5.84

 

4.26

1.64

acyltransferase

pme-5

5.68

 

3.01

1.09

poly(ADP-ribose) polymerase (PARP)

ugt-19

5.43

 

8.95

0.71

UDP-glucuronosyl/UDP-glucosyltransferase

T24C4.4

4.94

 

7.74

2.18

nematode specific

Y51A2B.1

4.44

 

9.44

1.38

Predicted riboflavin biosynthesis protein

gst-38

4.41

 

2.71

2.78

Glutathione S-transferase

C17H12.6

4.07

 

4.34

2.42

CUB-like domain, nematode specific

clec-4

4.05

 

16.41

4.15

C-type lectin/CUB domain

C34H4.2

4.05

 

5.87

1.59

DUF274, nematode specific

Y94H6A.10

4.03

 

3.51

0.92

nematode specific

M02F4.7

4.01

 

4.77

1.53

C-type lectin

F53B2.5

3.85

 

2.81

1.33

Importin alpha-1 subunit

C32H11.4

3.82

 

3.94

2.69

CUB-like domain, nematode specific

F40F12.7

3.66

 

3.27

1.33

CREB binding protein/P300

T16G1.6

3.65

 

1.30

0.71

Predicted small molecule kinase/DUF227

T19D12.4

3.63

 

4.11

1.65

von Willebrand factor type A

lys-2

3.52

3.8 ± 1.2

4.90

3.55

lysozyme

F49F1.7

3.46

 

5.24

4.64

ShK domain-like, Secreted surface protein

arf-1.1

3.29

 

4.01

2.11

ADP-ribosylation factor

C10C5.2

3.24

3.7 ± 1.2

3.81

1.52

Cyclin-like F-box, nematode specific

F36G9.12

3.18

 

4.13

2.07

acyltransferase

dod-17

3.15

 

4.55

2.95

CUB-like domain/downstream of daf-16 , nematode specific

ZK896.5

3.15

 

3.79

2.68

CUB-like domain, nematode specific

dod-24

3.04

 

3.07

3.19

CUB-like domain/downstream of daf-16 , nematode specific

egl-1

2.39

5.0 ± 0.3

2.91

2.49

BH3 domain-only protein, programmed cell death activator

  1. Genes were annotated according to Wormbase [31]. Bold type denotes genes significantly upregulated at least 2 fold 2 h and 6 h after IR. Values correspond to fold changes. Exemplary confirmation of transcriptional induction by qRT-PCR is shown.
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BMC Genomics

ISSN: 1471-2164

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