Evolutionary conservation of zinc finger transcription factor binding sites in promoters of genes co-expressed with WT1 in prostate cancer

Table 2 Genes co-expressed with WT1 in prostate cancer epithelium ^a

Gene symbol	Gene name	Synonyms	Ensembl gene ID	Entrez gene ID	Summary of function ^b	Regulation ^c,d	Binding ^c,e	Expression in prostate
ECAD	cadherin 1, type 1, E-cadherin (epithelial)	CDH1	ENSG00000039068	999	signaling		+	[90]
EGR1	early growth response 1	TIS8, GOS30, AT225	ENSG00000120738	1958	TF	+, ++	+	[11, 12]
GATA2	GATA binding protein 2	NFE1B	ENSG00000179348	2624	TF	+, ++	+	[56]
IGFBP2	insulin-like growth factor binding protein-2	IBP2	ENSG00000115457	3485	signaling	+	+, ++	[91–93]
KLK3	kallikrein 3, (prostate specific antigen)	PSA	ENSG00000142515	354	enzyme, signaling		++	[48, 49, 94]
NDRG1	N-myc downstream regulated gene 1	DRG1, RTP, TDD5, NDR1	ENSG00000104419	10397	enzyme		++	[63, 95, 96]
NPY	neuropeptide Y	PYY4	ENSG00000122585	4852	signaling		+	[97, 98]
SOX4	SRY (sex determining region Y)-box-4		ENSG00000124766	6659	TF	+, ++	+	[99, 100]
SOX9	SRY (sex determining region Y)-box-9	CMD1, CMPD1, SRA1	ENSG00000125398	6662	TF	+, ++	+	[101, 102]
TFAP2C	transcription factor AP-2 gamma	ERF1, TFAP2G	ENSG00000087510	7022	TF	+, ++	+	[89]
WT1	Wilms tumor 1	WAGR, WIT-2, GUD	ENSG00000184937	7490	TF	+, ++	+	[10, 84]

^a Genes expressed in prostate cancer epithelial cells [6] include those listed in additional file 1.
^b Function as defined in the respective SwissProt annotation [103].
^c Broad functional categories are based on Gene Ontology [104] functional annotation by DAVID [105].
^d + designates GOTERM_BP_ALL:regulation of biological process, ++ designates GOTERM_BP_ALL:regulation of transcription, GOTERM_BP_ALL:regulation of metabolism.
^e + designates GOTERM_MF_ALL:binding, ++ designates GOTERM_MF_ALL:protein binding.

ISSN: 1471-2164