Evolutionary conservation of zinc finger transcription factor binding sites in promoters of genes co-expressed with WT1 in prostate cancer

Table 3 TFBS in promoters of genes expressed in prostate cancer are conserved between Human and Primates or Rodents

Gene		WT1		EGR1		SP1		SP2		AP2		GATA1
	Conserved between^a	#Cons. sites^b	Total#^c	#Cons. sites^b	Total# ^c	#Cons. sites^b	Total#^c	#Cons. sites^b	Total#^c	#Cons. sites^b	Total#^c	#Cons. sites^b	Total#^c
*ECAD*	H-Pr	1/PA	2	1/0	1	3/0	4	1/0	2	1/PA	1	NP/NP	NP
	H-Ro	0/0		PA/PA		0/0		0/0		0/0		NP/NP
*EGR1*	H-Pr	4/4	8	7/8	10	3/4	7	1/0	1	1/1	1	3/1	3
	H-Ro	2/2		3/4		2/2		0/0		0/0		1/0
*GATA2*	H-Pr	7/8	8	1/1	1	3/4	5	3/2	3	2/3	3	NP/NP	NP
	H-Ro	1/2		PA/PA		1/0		0/0		0/0		NP/NP
*IGFBP2*	H-Pr	3/2	3	6/6	6	6/3	7	1/1	1	NP/NP	NP	3/1	3
	H-Ro	0/0		3/1		1/1		0/0		NP/NP		0/0
*KLK3*	H-Pr	2/2	3	1/1	1	1/1	2	1/0	1	NP/NP	NP	1/1	2
	H-Ro	NSA/NSA		NSA/NSA		NSA/NSA		NSA/NSA		NSA/NSA		NSA/NSA
*NDRG1*	H-Pr	1/1	1	NP/NP	NP	NP/NP	NP	NP/NP	NP	0/1	1	1/1	1
	H-Ro	0/0		NP/NP		NP/NP		NP/NP		0/0		0/0
*NPY*	H-Pr	9/7	9	2/1	2	4/4	4	2/2	2	4/2	5	2/2	2
	H-Ro	1/1		0/0		1/1		1/0		0/0		0/0
*SOX4*	H-Pr	2/1	2	2/2	2	3/3	3	1/1	1	NP/NP	NP	2/2	2
	H-Ro	1/1		0/0		2/2		0/0		NP/NP		2/2
*SOX9*	H-Pr	3/2	4	1/1	1	4/4	4	NP/NP	NP	NP/NP	NP	NP/NP	NP
	H-Ro	0/1		0/PA		1/NA		NP/NP		NP/NP		NP/NP
*TFAP2C*	H-Pr	NP/NP	NP	4/4	4	5/4	8	NP/NP	NP	1/1	1	NP/NP	NP
	H-Ro	NP/NP		3/3		2/2		NP/NP		1/1		NP/NP
*WT1*	H-Pr	4/2	7	3/3	3	3/3	6	1/1	1	2/1	4	1/0	5
	H-Ro	1/1		0/0		2/2		0/0		1/0		0/0

^a H-Pr = TFBS conserved between human and other primates (chimpanzee/macaque), H-Ro = TFBS conserved between human and rodents (mouse/rat).
^b Number of conserved sites: PA = only partial alignment of promoters as constructed by MultiPipMaker [79], NP = no TFBS in human promoters as predicted by the MatIspector [75], 0 = TFBS not conserved, and NSA = no orthologous sequence is available in Ensembl.
^c Total number of predicted sites is based on TFBS in human promoters.

ISSN: 1471-2164