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Table 5 Summary of evolutionary conserved sites shared between genomes of human and other species

From: Evolutionary conservation of zinc finger transcription factor binding sites in promoters of genes co-expressed with WT1 in prostate cancer

 

WT1

EGR1

SP1

SP2

AP2

GATA1

Total # of TFBS a

47

31

50

12

16

18

Primates

      

Chimpanzee

36 (77%)

28 (90%)

35 (70%)

11 (92%)

11 (69%)

13 (72%)

Macaque

28 (60%)

25 (81%)

27 (54%)

6 (50%)

9 (56%)

8 (44%)

Primate % conserved b

68%

85%

62%

71%

63%

58%

Rodents

      

Mouse

6 (13%)

9 (29%)

12 (24%)

1 (8%)

2 (13%)

3 (17%)

Rat

8 (17%)

8 (26%)

10 (20%)

0 (0%)

1 (6%)

2 (11%)

Rodent % conserved c

15%

26%

22%

4%

9%

14%

Marsupials

      

Opossum

3

6

6

0

1

0

% conserved

6%

19%

12%

0%

6%

0%

  1. a Total # of TFBS = The total number of TFBS predicted by MatIspector [75] based on TFBS in human promoters of 11 genes. Numbers of evolutionary conserved TFBS shared between human and each species are shown below (percent of sites conserved shown in parenthesis).
  2. b Primate % conserved = Average number of chimpanzee and macaque evolutionary conserved TFBS divided by the total number of TFBS predicted for that particular TF.
  3. c Rodent % conserved = Average number of mouse and rat evolutionary conserved TFBS divided by the total number of TFBS for that particular TF.