Table 5 Differential expression in daunorubicin-treated versus non-treated cells, measured by RT-qPCR
From: Selective inhibition of yeast regulons by daunorubicin: A transcriptome-wide analysis
Treated/Non treateda) | ||||||||
|---|---|---|---|---|---|---|---|---|
Function | ORF | Time 0 | Time 4 h | Fold variation (4 h/0 h) | p b) | Corrected p (Bonferroni) | n (technical replicates) | n (biological replicates) |
ACO1 | 0.001 | -1.090 | 0.470 | 0.001 | 0.020 | 60 | 5 | |
CDC19 | 0.034 | -1.132 | 0.446 | 6.3 × 10-13 | 9.5 × 10-12 | 108 | 5 | |
FBA1 | 0.005 | -1.207 | 0.432 | 1.0 × 10-13 | 1.5 × 10-12 | 60 | 5 | |
GPM1 | -0.005 | -0.948 | 0.520 | 3.0 × 10-8 | 4.5 × 10-7 | 60 | 5 | |
Energy metabolism | HOR2 | -0.010 | -1.413 | 0.378 | 9.0 × 10-4 | 0.014 | 24 | 2 |
HXK1 | 0.315 | -1.935 | 0.210 | 1.6 × 10-21 | 2.5 × 10-20 | 72 | 5 | |
PGI1 | 0.005 | -0.061 | 0.956 | 0.80 | > 0.05 | 60 | 5 | |
PGK1 | 0.005 | -1.228 | 0.425 | 8.9 × 10-19 | 1.3 × 10-17 | 60 | 5 | |
TDH | -0.015 | -1.428 | 0.375 | 5.9 × 10-12 | 8.8 × 10-11 | 60 | 5 | |
ARG1 | -0.010 | -2.032 | 0.246 | 2.1 × 10-7 | 3.2 × 10-6 | 24 | 2 | |
Amino acid metabolism | ARG4 | -0.001 | -1.413 | 0.376 | 5.3 × 10-6 | 8.0 × 10-5 | 23 | 2 |
CAR2 | -0.011 | -0.294 | 0.822 | 0.09 | > 0.05 | 35 | 3 | |
ACT1 | -0.480 | -1.440 | 0.514 | 0.126 | > 0.05 | 8 | 3 | |
Others | HSP26 | 0.081 | -2.921 | 0.125 | 5.1 × 10-8 | 7.6 × 10-7 | 24 | 2 |
RPS28A | -0.005 | 0.476 | 1.396 | 0.002 | 0.028 | 60 | 5 | |
TPS2 | 0.002 | 0.120 | 1.086 | 0.42 | > 0.05 | 22 | 2 | |