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Table 6 Transcription factors preferently associated to DNR-inhibited genes

From: Selective inhibition of yeast regulons by daunorubicin: A transcriptome-wide analysis

Factor

Total regulated genesa)

DNR-down regulated genes

p

  

Observed

Expected (out of 280)

Observed/Expected

Hypergeometric

Bonferroni

Sok2p

561

118

45.45

2.6

5.6 × 10-27

7.2 × 10-25

Msn2p

316

72

25.58

2.8

2.0 × 10-17

2.6 × 10-15

Msn4p

286

67

23.13

2.9

8.3 × 10-17

1.1 × 10-14

Gis1p

91

35

7.35

4.8

1.5 × 10-16

1.9 × 10-14

Cst6p

104

36

8.44

4.3

4.0 × 10-15

5.1 × 10-13

Pdr3p

84

29

6.8

4.3

2.4 × 10-12

3.1 × 10-10

Yap1p

1025

133

83

1.6

2.1 × 10-11

2.8 × 10-9

Met4p

746

105

60.42

1.7

8.8 × 10-11

1.1 × 10-8

Adr1p

148

36

11.97

3.0

3.6 × 10-10

4.6 × 10-8

Xbp1p

84

26

6.8

3.8

5.3 × 10-10

6.9 × 10-8

Rox1p

202

44

16.33

2.7

6.2 × 10-10

7.9 × 10-8

Aft1p

397

66

32.11

2.1

9.5 × 10-10

1.2 × 10-7

Crz1p

155

37

12.52

3.0

1.4 × 10-9

1.8 × 10-7

Pdr1p

205

42

16.6

2.5

3.9 × 10-9

5.1 × 10-7

Skn7p

215

44

17.42

2.5

5.4 × 10-9

7.0 × 10-7

Gcn4p

309

54

25.04

2.2

7.8 × 10-9

1.0 × 10-6

Stp2p

131

32

10.61

3.0

1.5 × 10-8

2.0 × 10-6

Hsf1p

266

48

21.5

2.2

5.2 × 10-8

6.7 × 10-6

Mig1p

74

21

5.99

3.5

1.1 × 10-7

1.4 × 10-5

Ino2p

81

22

6.53

3.4

1.2 × 10-7

1.6 × 10-5

Gcr2p

97

25

7.89

3.2

2.8 × 10-7

3.6 × 10-5

Mga1p

151

31

12.25

2.5

4.6 × 10-7

5.9 × 10-5

Mbp1p

242

42

19.59

2.1

4.6 × 10-7

5.9 × 10-5

Rfx1p

87

23

7.08

3.2

6.0 × 10-7

7.7 × 10-5

Stp1p

91

23

7.35

3.1

1.1 × 10-6

1.4 × 10-4

Rtg3p

108

24

8.71

2.8

1.9 × 10-6

2.4 × 10-4

Swi4p

302

47

24.49

1.9

2.5 × 10-6

3.3 × 10-4

Rgt1p

44

14

3.54

4.0

2.9 × 10-6

3.7 × 10-4

Ino4p

333

50

26.94

1.9

3.1 × 10-6

4.0 × 10-4

Sut1p

34

12

2.72

4.4

4.1 × 10-6

5.3 × 10-4

Gat4p

64

18

5.17

3.5

4.5 × 10-6

5.8 × 10-4

Nrg1p

168

31

13.61

2.3

4.7 × 10-6

6.1 × 10-4

  1. a) Number of genes associated to each factor, following YEASTRACT. Only genes used in the microarray analysis (3458) were considered.