Table 7 Transcription factors selectively enriched in daunorubicin-down regulated gene promoters
From: Selective inhibition of yeast regulons by daunorubicin: A transcriptome-wide analysis
Factor | Found/expected | p a) | Binding sequences | CpG steps | Characteristics/Function |
|---|---|---|---|---|---|
Gis1p | 4.76 | 1.9 × 10-14 | TWAGGGAT, AGGGG | JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1 | |
Sut1p | 4.41 | 5.3 × 10-4 | CGCG | * | Transcription factor of the Zn [II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression |
Cst6p | 4.27 | 5.1 × 10-13 | TGACGTCA, TTACGTAA | * | Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of genes involved in utilization of non-optimal carbon sources; involved in telomere maintenance |
Pdr3p | 4.26 | 3.1 × 10-10 | TCCGCGGA | * | Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements) |
Rgt1p | 3.95 | 3.7 × 10-4 | CGGANNA | * | Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor |
Xbp1p | 3.82 | 6.9 × 10-8 | GCCTCGARMGA | * | Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate |
Mig1p | 3.51 | 1.4 × 10-5 | W(4-5)GCGGGG | * | Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase |
Gat4p | 3.48 | 5.8 × 10-4 | GATA | Protein containing GATA family zinc finger motifs | |
Ino2p | 3.37 | 1.6 × 10-5 | WYTTCAYRTGS | * | Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion |
Rfx1p | 3.25 | 7.7 × 10-5 | TCRYYRYRGCAAC | * | Protein involved in DNA damage and replication checkpoint pathway; recruits repressors Tup1p and Cyc8p to promoters of DNA damage-inducible genes; similar to a family of mammalian DNA binding RFX1-4 proteins |
Gcr2p | 3.17 | 3.6 × 10-5 | CTTCC, CWTCC (Gcr1p) | Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA binding protein Gcr1p | |
Stp1p | 3.13 | 1.4 × 10-4 | CGGCN(6)CGGC | * | Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing |
Stp2p | 3.02 | 2.0 × 10-6 | CGGGGTGN(7)CGCACCG | * | Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes |
Adr1p | 3.01 | 4.6 × 10-8 | TTGGRGN(6-38)CYCCAA | Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization |