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Table 3 Selected Parkinson's disease two-locus combinations.

From: A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis

SNP1 SNP2 Effect Genetic Model Odds Ratio 2-locus X2 Case-only X2
rs6542522 rs3923511 E TC*GA 0.28 24.97 13.07
rs10799573 rs1341622 E CC*CT 5.22 23.08 10.61
rs12520264 rs2992630 E AG*GA 0.22 23.86 23.12
rs324454 rs12672177 E GG*AG 0.21 24.31 11.55
rs6656554 rs3898966 E GT*TC 3.83 23.44 22.34
rs7650598 rs12353255 E AG*AG 3.99 23.94 9.40
rs2439525 rs1327918 E TT*CC 2.39 22.04 7.13
rs10201616 rs4495512 E CT*TT 5.04 24.08 8.63
rs11167062 rs1270919 E TC*GT 0.20 21.83 20.65
rs2419117 rs10512174 E GT*CC 5.55 23.33 9.33
rs1370699 rs1673130 C CC*CC 0.35 25.50 30.15
rs1590957 rs8043401 C TT*AG 0.32 24.17 28.18
rs1557615 rs2582597 C TC*AG 0.35 21.76 26.38
rs11781101 rs4775501 C CC*CC 0.22 23.99 25.69
rs1370699 rs7897163 C CC*CC 0.34 30.65 25.68
rs13197142 rs2206699 C GG*AA 2.33 21.85 25.16
rs732594 rs12373417 C AA*GG 3.62 22.31 25.16
rs10498269 rs1551355 C TC*CC 0.38 23.42 25.00
rs2555614 rs331617 C AA*TT 0.35 24.15 24.22
rs3894377 rs10774863 C AG*CT 0.31 25.47 23.84
rs4799327 rs2301661 S AG*CC 4.32 20.65 33.62
rs2336865 rs7973385 S GA*TC 3.22 30.71 27.77
rs6779648 rs270406 S GG*AG 0.26 26.57 22.49
rs12599027 rs767055 S TT*TT 0.23 26.23 24.34
rs3891371 rs4724620 S AG*CC 0.29 35.76 23.92
rs2297518 rs660454 S AG*TT 0.12 23.92 23.72
rs357968 rs1159145 S AA*AA 0.26 30.29 23.47
rs1476097 rs5766305 S TT*TT 0.37 23.93 23.19
rs2955005 rs2169793 S GT*AG 3.29 25.74 22.76
rs2560790 rs9390939 S AA*CA 0.32 23.35 22.62
  1. A selection of two-locus marker combinations consistently and significantly associated to Parkinson's disease (p < 10-6) and displaying an epistatic (E) effect, or conditional (C) or simultaneous (S) effects with significant deviations of a multiplicative model. The genetic model tested is specified as SNP1 genotype * SNP2 genotype.