Figure 9

A proposed model for generation of the observed anomalous p44 conserved sequence transcripts (sense and anti-sense). "Read through" transcription of genes lying just upstream of anti-sense p44 sequence (e.g. "Gene 1" and msp4) may produce anti-sense p44 transcript, which, together with p44 sense transcript, forms double stranded RNA (dsRNA). Because the HVR sequences are not complementary they do not form dsRNA and are therefore degraded. However, the conserved, complementary sequences do form dsRNA so are stabilized, accumulate in the bacteria, and are measured as over-abundant by the arrays.