Figure 6
From: Gene networks driving bovine milk fat synthesis during the lactation cycle
Networks among genes involved in milk fat synthesis. Networks were developed with Ingenuity Pathway Analysis® (Ingenuity Systems, http://www.ingenuity.com) and edited to incorporate results from the present and previous studies in bovine mammary tissue. Red nodes denote positive fold changes and green nodes negative fold changes in expression at 60 relative to -15 d. Red, blue, and green edges denote genes whose transcription is under the control of SREBF1, SREBF2, and PPARG, respectively. Highlighted in orange is the network encompassing PPARG, PPARGC1A, LPIN1, INSIG1, and SCAP which controls expression/function of SREBF proteins. Letters along the edges denote effects on activity (A), expression (E), localization (LO), proteolysis (L), RNA binding (RB), protein-DNA binding (PD), and protein-protein binding (PP). Genes are grouped based on their primary function during milk fat synthesis.