Enriched transcription factors and their putative target genes in disease progression. Putative targets of transcription factors were curated based on results by Xiaohui Xie. Fisher Exact test showed that two transcription factors (AP-1 and CREB) were significantly enriched in disease progression (q-value <0.05). AP-1 and CREB were enriched to regulate 72 and 55 genes expression, respectively. A, B. The top 20 putative target genes of AP-1 and CREB were listed, respectively. A list of the enriched transcription factor and their putative targets is provided [see Additional file 10 and Additional file 11].