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Table 4 GO discovered categories for disease progression manner analysis

From: Peripheral arterial occlusive disease: Global gene expression analyses suggest a major role for immune and inflammatory responses

GO Name Z-Score P-value
For Cluster I   
immune response 8.908 0.000
inflammatory response 7.643 0.000
cellular defense response 5.938 0.001
chemotaxis 7.611 0.000
cell surface receptor linked signal transduction 2.937 0.009
cytokine and chemokine mediated signaling pathway 4.378 0.004
JAK-STAT cascade 3.254 0.020
MAPKKK cascade 3.062 0.006
endocytosis 1.956 0.049
angiogenesis 4.452 0.000
cell adhesion 4.580 0.000
ion homeostasis 3.090 0.010
For Cluster II   
apoptosis 3.871 0.002
cell cycle 4.108 0.000
cell growth 2.285 0.037
epidermal cell differentiation 3.075 0.044
protein folding 3.677 0.001
macromolecule metabolic process 3.022 0.005
RNA metabolic process 5.378 0.000
transcription 4.593 0.000
peripheral nervous system development 2.950 0.046
multicellular organismal development 3.927 0.000
vitamin transport 4.426 0.008
response to stimulus 4.579 0.000
circadian rhythm 5.090 0.001
For Cluster III   
neurogenesis 2.612 0.014
neuron recognition 3.315 0.046
cell motility 2.093 0.042
glycogen metabolic process 2.999 0.025
protein modification process 3.166 0.001
RNA processing 2.183 0.042
RNA splicing 2.591 0.021
phosphate metabolic process 2.346 0.024
blood pressure regulation 4.028 0.008
heart contraction 2.901 0.022
  1. GO analysis was applied to differentially expressed genes in each cluster group. Some selected categories are shown. The Calculated p-values and Z-scores for each category are shown. The detailed GO results are provided in the additional data [see Additional file 9].