Table 4 Functional categories of genes regulated by the Zap1 transcriptional factor.

First-line defenses: Zinc homeostasis

   Zinc uptake

ZRT1, ZRT2, FET4, ZPS1

   Mobilize zinc stores

ZRT3

   Increase transcription response

ZAP1

   Zinc sparing

ZRR1 (ADH1), ZRR2 (ADH3), ADH4

   Zinc shock resistance

ZRC1

   Other zinc homeostasis genes

IZH1, IZH2

Second-line defenses: Adaptive responses

   Secretory pathway function

ZRG17, MNT2, MCD4, YJR061W

   Cell wall function

PST1, BAG7, HSP12, SED1, SCW4, YOL155C, YIL169C, YJL171C

   Stress resistance

GRE2, RAD27, TSA1, CTT1, UTH1, HSP26

   Phospholipid metabolism

DPP1, EKI1, PIS1, YJL132W

   Sulfur metabolism

LAP3, SAM3, YPR003C

   Protein degradation

PRC1, PEP4, PRB1, ATG19, UBX6

   Carbohydrate metabolism

NRG2, TKL2, ENO1, ENO2, TDH1

   Purine/pyrimidine metabolism

URA10, ADE17, HNT1

   Mitochondrial function

FMP43, PET20, PET10

Other

VEL1, MOH1, GPG1, COS6, ICY2, COS1, PHM7, PIG2, TIS11, ALD3, PUT4 , COS2, ZIP1, COS4, COS8, TPO5, COS3, YNL254C, YOR387C, YLL020C, YOL131W, YBL029W, YHR214W-A, YMR181C, YLL053C , YBL048C, YMR086W, YNL234W