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Table 3 Immune-related responses of human intestinal mucosal cells to L. plantarum WCFS1

From: Identification of the transcriptional response of human intestinal mucosa to Lactobacillus plantarum WCFS1 in vivo

component function regulation after 1 hr exposure regulation after 6 hrs exposure
IL-1 interleukin-1 cytokine, induction immune responses -
IL-1R receptor for interleukin-1 (IL-1) -
IF complement factor I, serine protease, activator of complement pathway of innate immune response -
CFD (adipsin) serine protease, activator of complement pathway of innate immune response -
C1R serine protease, activator of complement pathway of innate immune response and GPCR 1 pathway -
C1S serine protease, activator of complement pathway of innate immune response and GPCR 1 pathway -
C8G part of antibacterial membrane attack complex (MAC) -
CD74 TM receptor, antigen presentation, immune response and humoral defence -
CD93 cell-surface glycoprotein, part of complement component 1, activator of macrophage and cellular adhesion -
HLA-A * regulation of NK cell cytotoxicity -
HLA-C endogenous antigen presentation -
HLA-E immune response regulation, protection from NK cells -
HLA-G regulatory/suppressive to T cells, cytokine tolerance -
HLA-DMA antigen presentation, detection of microbes, CLIP release -
HLA-DMB antigen presentation, detection of microbes, CLIP release -
HLA-DPA1 antigen presentation derived from extracellular proteins -
HLA-DRA antigen presentation derived from extracellular proteins
HLA-DRB1 antigen presentation derived from extracellular proteins -
  1. 1 G-protein coupled receptor
  2. * HLA (human leukocyte antigen) are transmembrane receptors that are all part of MHC complex pathway, HLA-x are class I, HLA-Dxxx are class II paralogues.
  3. Green triangles refer to downregulation, and red triangles to upregulation of genes related to immune responses.