Skip to main content
Figure 2 | BMC Genomics

Figure 2

From: Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions

Figure 2

Unsupervised hierarchical clustering analysis of A549 probe sets in which the expression was altered by crocidolite. (A) The main dendogram represents the intensity of each probe set in relation to the entire data set with green being low and red being high. Four major clusters of upregulated genes and two clusters of downregulated genes were observed and are shown as bracketed dendograms where the color represents the intensity of each probe set in relation to each specific cluster. (B) STRING analysis using the genes within the upregulated clusters demonstrated a functional relationship between 24 of the genes which encompassed cytokine, MAPkinase and JNK/SAPK signaling pathways.

Back to article page