Figure 4
Spatial depiction of the top scoring network and canonical pathways detected in crocidolite-treated A549 cells by Ingenuity Pathway® Analysis. The network was algorithmically generated based on the connectivity of each of the transcripts and the molecular interaction knowledge base. Each node represents a gene or gene product for which mRNA expression was upregulated (red) or downregulated (blue) in crocidolite-treated A549 cells. Edges/lines connecting the nodes represent molecular interactions between genes and/or gene products and are supported by at least one reference from the literature, a textbook, or from canonical pathway information stored in the Ingenuity Pathways Knowledge Base. The Nrf2-mediated oxidative stress canonical pathway identified by Pathway Analysis software shows differential upregulation of select genes within the cytoprotective arsenal.