Figure 5

Pathway analysis of representative genes involved in the response of A549 cells exposed to crocidolite. In (A) the top five scoring networks were merged to create a cellular model consisting of ~150 genes for which expression levels changed ± 2-fold and demonstrated p-values less than 0.01. Nodes representing genes are colored red for upregulation or blue for downregulation and the intensity of the color reflects the degree of up- or downregulation. Lines connecting the nodes are indicators of interactions found in the knowledge database or current literature. In (B) and (C) the networks surrounding PTGS2, SMARCA4, and PTEN have been expanded for clarity. In (D) the relationship between E2F1 and TNF is observed.