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Table 1 List of genes for which expression increased five-fold or greater or decreased two-fold or greater

From: Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions

Fold Change

Gene Symbol

Gene Name

115.7

EGR1

Early growth response 1

38.3

FOS

v-Fos FBJ murine osteosarcoma viral oncogene homolog

25.3

ATF3

Activating transcription factor 3

19.5

GEM

GTP binding protein overexpressed in skeletal muscle

17.1

NR4A2

Nuclear receptor subfamily 4, group A, member 2

16.6

IL8

Interleukin 8

15.9

FST

Follistatin

15.6

PPP1R15A

Protein phosphatase 1, regulatory (inhibitor) subunit 15A

13.7

STC1

Stanniocalcin 1

12.1

MAFF

v-Maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)

11.2

CXCL2

Chemokine (C-X-C motif) ligand 2

10.4

TNFAIP3

Tumor necrosis factor, alpha-induced protein 3

9.4

MXD1

MAX dimerization protein 1

9.1

ARID5B

AT rich interactive domain 5B (MRF1-like)

9.0

NR4A3

Nuclear receptor subfamily 4, group A, member 3

8.6

JUN

v-Jun sarcoma virus 17 oncogene homolog (avian)

7.8

LOC153222

adult retina protein

7.4

BRE

brain and reproductive organ-expressed (TNFRSF1A modulator)

7.2

MCTP1

Multiple C2 domains, transmembrane 1

7.2

DDIT3

DNA-damage-inducible transcript 3

7.2

FOSB

FBJ murine osteosarcoma viral oncogene homolog B

7.1

GDF15

Growth differentiation factor 15

6.9

CITED2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

6.9

DUSP6

Dual specificity phosphatase 6

6.6

CXCL1

Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

6.5

IL24

Interleukin 24

6.3

SPRY2

Sprouty homolog 2 (Drosophila)

6.1

PTGS2

Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

6.0

KLF6

Kruppel-like factor 6

6.0

IL11

Interleukin 11

5.6

IRAK2

Interleukin-1 receptor-associated kinase 2

5.5

IL6

Interleukin 6 (interferon, beta 2)

5.5

HIST1H4H

Histone 1, H4h

5.4

FNIP1

folliculin interacting protein 1

5.3

HIST2H2BE

Histone 2, H2be

5.2

MCL1

Myeloid cell leukemia sequence 1 (BCL2-related)

5.1

DUSP10

Dual specificity phosphatase 10

5.1

DHRS2

Dehydrogenase/reductase (SDR family) member 2

5.1

SYNE1

Spectrin repeat containing, nuclear envelope 1

5.1

HAS2

Hyaluronan synthase 2

5.1

PER1

period homolog 1 (Drosophila)

5.1

ZBTB10

zinc finger and BTB domain containing 10

-2.0

FN1

Fibronectin 1

-2.0

BCL2L11

BCL2-like 11 (apoptosis facilitator)

-2.0

COL5A1

collagen, type V, alpha 1

-2.0

VAV3

vav 3 oncogene

-2.0

CSRP2BP

CSRP2 binding protein

-2.0

PRSS23

protease, serine, 23

-2.1

NRP2

Neuropilin 2

-2.1

DAPK1

Death-associated protein kinase 1

-2.1

CDH1

Cadherin 1, type 1, E-cadherin (epithelial)

-2.2

ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

-2.2

RNASE4

Ribonuclease, RNase A family, 4

-2.2

FGG

Fibrinogen gamma chain

-2.1

STAT4

Signal transducer and activator of transcription 4

-2.1

NTRK3

Neurotrophic tyrosine kinase, receptor, type 3

-2.3

PCDH9

Protocadherin 9

-2.2

CYP4F3

Cytochrome P450, family 4, subfamily F, polypeptide 3

-2.2

ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

-2.3

MAP2K6

Mitogen-activated protein kinase kinase 6

-2.3

LXN

latexin

-2.3

TM4SF20

transmembrane 4 L six family member 20

-2.4

AKR1C1///AKR1C2

Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)///aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)

-2.7

SLC40A1

Solute carrier family 40 (iron-regulated transporter), member 1

  1. A549 human lung epithelial cells were exposed to crocidolite asbestos at 6 g/cm2 for 24 h. Genes for which expression levels increased 5.0 fold or greater, or decreased 2.0 fold or greater, having q values less than 0.05 are shown. Probe sets associated with products of unknown function were not included. Bold-faced genes were not observed in the statistically upregulated expression profile of hydrogen-peroxide-treated A549 cells [36]. A list of all genes for which expression levels changed 2.0 fold or greater can be found as Additional File 2.