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Table 1 List of genes for which expression increased five-fold or greater or decreased two-fold or greater

From: Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions

Fold Change Gene Symbol Gene Name
115.7 EGR1 Early growth response 1
38.3 FOS v-Fos FBJ murine osteosarcoma viral oncogene homolog
25.3 ATF3 Activating transcription factor 3
19.5 GEM GTP binding protein overexpressed in skeletal muscle
17.1 NR4A2 Nuclear receptor subfamily 4, group A, member 2
16.6 IL8 Interleukin 8
15.9 FST Follistatin
15.6 PPP1R15A Protein phosphatase 1, regulatory (inhibitor) subunit 15A
13.7 STC1 Stanniocalcin 1
12.1 MAFF v-Maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
11.2 CXCL2 Chemokine (C-X-C motif) ligand 2
10.4 TNFAIP3 Tumor necrosis factor, alpha-induced protein 3
9.4 MXD1 MAX dimerization protein 1
9.1 ARID5B AT rich interactive domain 5B (MRF1-like)
9.0 NR4A3 Nuclear receptor subfamily 4, group A, member 3
8.6 JUN v-Jun sarcoma virus 17 oncogene homolog (avian)
7.8 LOC153222 adult retina protein
7.4 BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
7.2 MCTP1 Multiple C2 domains, transmembrane 1
7.2 DDIT3 DNA-damage-inducible transcript 3
7.2 FOSB FBJ murine osteosarcoma viral oncogene homolog B
7.1 GDF15 Growth differentiation factor 15
6.9 CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
6.9 DUSP6 Dual specificity phosphatase 6
6.6 CXCL1 Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
6.5 IL24 Interleukin 24
6.3 SPRY2 Sprouty homolog 2 (Drosophila)
6.1 PTGS2 Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
6.0 KLF6 Kruppel-like factor 6
6.0 IL11 Interleukin 11
5.6 IRAK2 Interleukin-1 receptor-associated kinase 2
5.5 IL6 Interleukin 6 (interferon, beta 2)
5.5 HIST1H4H Histone 1, H4h
5.4 FNIP1 folliculin interacting protein 1
5.3 HIST2H2BE Histone 2, H2be
5.2 MCL1 Myeloid cell leukemia sequence 1 (BCL2-related)
5.1 DUSP10 Dual specificity phosphatase 10
5.1 DHRS2 Dehydrogenase/reductase (SDR family) member 2
5.1 SYNE1 Spectrin repeat containing, nuclear envelope 1
5.1 HAS2 Hyaluronan synthase 2
5.1 PER1 period homolog 1 (Drosophila)
5.1 ZBTB10 zinc finger and BTB domain containing 10
-2.0 FN1 Fibronectin 1
-2.0 BCL2L11 BCL2-like 11 (apoptosis facilitator)
-2.0 COL5A1 collagen, type V, alpha 1
-2.0 VAV3 vav 3 oncogene
-2.0 CSRP2BP CSRP2 binding protein
-2.0 PRSS23 protease, serine, 23
-2.1 NRP2 Neuropilin 2
-2.1 DAPK1 Death-associated protein kinase 1
-2.1 CDH1 Cadherin 1, type 1, E-cadherin (epithelial)
-2.2 ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
-2.2 RNASE4 Ribonuclease, RNase A family, 4
-2.2 FGG Fibrinogen gamma chain
-2.1 STAT4 Signal transducer and activator of transcription 4
-2.1 NTRK3 Neurotrophic tyrosine kinase, receptor, type 3
-2.3 PCDH9 Protocadherin 9
-2.2 CYP4F3 Cytochrome P450, family 4, subfamily F, polypeptide 3
-2.2 ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
-2.3 MAP2K6 Mitogen-activated protein kinase kinase 6
-2.3 LXN latexin
-2.3 TM4SF20 transmembrane 4 L six family member 20
-2.4 AKR1C1///AKR1C2 Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)///aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
-2.7 SLC40A1 Solute carrier family 40 (iron-regulated transporter), member 1
  1. A549 human lung epithelial cells were exposed to crocidolite asbestos at 6 g/cm2 for 24 h. Genes for which expression levels increased 5.0 fold or greater, or decreased 2.0 fold or greater, having q values less than 0.05 are shown. Probe sets associated with products of unknown function were not included. Bold-faced genes were not observed in the statistically upregulated expression profile of hydrogen-peroxide-treated A549 cells [36]. A list of all genes for which expression levels changed 2.0 fold or greater can be found as Additional File 2.