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Table 2 Validation of the microarray data from crocidolite-treated human A549 cells

From: Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions

Gene Alias for Protein Product Affymetrix* (fold change) this study QRT-PCR (fold change) this study Changes in mRNA levels in human cells observed by other groups
EGR1 Egr1 115.7 281.7 ± 3.8  
ATF3 ATF3 25.3 23.7 ± 0.1  
c-Jun c-Jun 8.6 10.5 ± 0.7  
JunB JunB 2.2 3.6 ± 0.2  
IL8 Interleukin 8 16.6 N.D. Increased [73]
TP53 p53 1.8 N.D. Increased [16, 74]
SOD2 Mn-SOD 2.2 N.D. Increased [75]
HMOX1 Heme oxygenase 1 2.1 N.D. Increased [75, 76]
c-myc myc 2.0 N.D. Increased [77]
CDKN1A p21, Cip1 1.9 N.D. Increased [16, 74]
  1. *represents significantly greater than control, q less than 0.05; N.D., not determined
  2. chrysotile-treated A549 human lung epithelial cells
  3. crocidolite-treated human pleural mesothelial cells