Complete genome of Phenylobacterium zucineum – a novel facultative intracellular bacterium isolated from human erythroleukemia cell line K562

Table 4 Transcriptional regulators in the P. zucineum genome

Family name	Action type	Chromosome	Plasmid	Proposed roles
AsnC family	Activator/repressor	8	0	Amino acid biosynthesis
AraC family	Activator	10	1	Carbon metabolism, stress response and pathogenesis
ArsR family	Repressor	8	0	Metal resistance
BlaI family	Repressor	2	0	Penicillin resistance
Cold shock family	Activator	6	0	Low-temperature resistance
Cro/CI family	Repressor	9	2	Unknown²
Crp/Fnr family	Activator/repressor	7	2	Global responses, catabolite repression and anaerobiosis
GntR family	Repressor	7	0	General metabolism
LacI family	Repressor	4	0	Carbon source utilization
LuxR family	Activator	5	1	Quorum sensing, biosynthesis and metabolism, etc.
LysR family	Activator/repressor	15	1	Carbon and nitrogen metabolism
MarR family	Activator/repressor	6	0	Multiple antibiotic resistance
MerR family	Repressor	9	2	Resistance and detoxification
TetR family	Repressor	22	0	Biosynthesis of antibiotics, efflux pumps, osmotic stress, etc.
XRE family	Repressor	2	2	Unknown (initial function is lysogeny maintenance)
Other types²	-	34	5	-
Total	-	154	16	-

¹Initial function is related to controlling the expression of phage gene
²"Other types" include the transcriptional regulators with only one member in the P. zucineum genome or transcriptional regulators that could not be classified into any known family.