Differential expression patterns of LPA and EGF. (A) Global transcriptional responses to LPA (5 μM) versus EGF (50 ng/ml) over time. Hierarchical clustering analysis was done on the 915-gene data set of Figure 5. (B) Heat map of 111 reporters (encoding 105 genes) that are differentially regulated by LPA (cyan) and EGF (red), or inversely regulated by either agonist (blue). See also additional file 8: heat map of selected genes. Numbers (1–9) refer to additional file 9, which shows a list of all 111 reporters. Genes were identified by Anova analysis (two groups, p < 0.01).