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Table 2 Differentially expressed chaperone and chaperone-related genes in artesunate-treated cells

From: Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate

Gene ID Description Pexel family ref ART 90 mn ART 3 h HS CQ
PFE1605w DNAJ protein yes resa like/dnaJ 1, 3   1,01   
PFD0080c hypothetical protein, conserved in P.falciparum yes resa like 3 1,31 1,82 +  
PF10_0378 DnaJ protein, putative yes Hsp40, type III 1, 2, 4 1,33 1,53 +  
PFE0040c mature parasite-infected erythrocyte surface antigen (MESA) or PfEMP2 yes Hsp40, type IV 2, 4 0,92 1,87   
PFA0660w protein with DNAJ domain, dnj1/sis1 family yes Hsp40, type II 1, 2, 4 1,01 1,34 +  
MAL7P1.7 RESA-like protein yes resa like 3   0,83   
PFL0050c hypothetical protein yes resa like 3   0,86   
PF07_0029 heat shock protein 86 no hsp90 1   0,9 +  
PF07_0030 heat shock protein 86 family protein no Hsp86 family 5   1,63 +  
PF08_0054 heat shock 70 kDa protein no hsp70 1   0,88 +  
PF11_0034 hypothetical protein yes Hsp40, type IV 1, 2, 4   0,81 +  
PFA0675w P. falciparum RESA-like protein with DnaJ domain yes Hsp40, type IV 1, 2, 4   1,96 +  
PF14_0700 hypothetical protein, conserved no Hsp40, type III 1, 2, 4   0,81   
PF11_0509 ring-infected erythrocyte surface antigen putative yes Hsp40, type IV 1, 2, 4   -1,14   
PF13_0102 DNAJ-like Sec63 homologue no Hsp40, type III 1, 2, 4   -1,04   
PF11_0216 hypothetical protein no Heat shock factor binding protein 1 6   -0,93 -  
PFC0975c PFCYP19, cyclophilin, peptidyl-prolyl cis-trans isomerase no cyclophillin 1   -0,97   
  1. Gene ID: identifier as found in PlasmoDB.
  2. Art columns: log ratios of gene expression under artesunate exposure at 90 minutes and 3 hours.
  3. HS column: over (+) or under (-) expression.
  4. Results were compared with transcriptome modifications induced by heat-shock (HS) [12] and chloroquine (CQ) [8].
  5. Chaperone- and chaperone-related genes were defined based on: 1) Acharya et al. [19], 2) Botha et al. [20], 3) resa-like annotation from GeneDB, 4) genes fitting the HMM profile of DNAJ (PF00226) from Pfam, 5) The Hsp86 family annotation from GeneDB, 6) genes fitting the HMM profile of heat shock factor binding protein 1 (PF06825) from Pfam.