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Table 7 Differentially expressed genes encoding kinases in artesunate-treated cells

From: Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate

Gene ID Description Kinase type Name ART 90 min ART 3 h HS CQ
PFL0040c protein kinase, R45/FIKK family R45/FIKK FIKK12 0,88 1,16   
MAL7P1.144 protein kinase, R45/FIKK family R45/FIKK FIKK7.1 0,90 1,82   
PFI0095c protein kinase, R45/FIKK family R45/FIKK FIKK9.1 0,83 1,28   
PF11_0510 protein kinase, R45/FIKK family R45/FIKK FIKK11   0,95   
PFD1165w protein kinase, R45/FIKK family R45/FIKK FIKK4.1   1,05   
PFL1885c calcium/calmodulin-dependent protein kinase 2, putative kinase PfPK2 1,35 1,21   
PFL2280w cyclin g-associated kinase, putative kinase    1,10   
PF14_0346 cGMP-dependent protein kinase 1, beta isozyme, putative kinase    1,03   
PF11_0242 protein kinase kinase    0,95   
PF14_0294 mitogen-activated protein kinase 1, PfMAP1 kinase PfMAP1   1,05   
PFD0975w ROI kinase-like protein RIO1    0,90   +
PF11_0377 casein kinase 1, PfCK1 kinase    -0,91   +
PF11_0227 serine/threonine protein kinase, puative kinase    -0,98   
PFB0150c protein kinase, putative kinase    -1,05   
  1. Gene ID: identifier as found in PlasmoDB.
  2. Art columns: log ratios of gene expression under artesunate exposure at 90 minutes and 3 hours.
  3. CQ column: over (+) or under (-) expression.
  4. Results were compared with transcriptome modifications induced by heat-shock (HS) [12] and chloroquine (CQ) [8].
  5. Kinases were defined as genes fitting the HMM profil kinase PF00069 (update of Ward et al. [39]) and ROI Kinases as genes fiiting the HMM profil PF01163. FIKK kinases were defined as described in Schneider and Puijalon [41].
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BMC Genomics

ISSN: 1471-2164

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