Skip to main content

Table 8 Differentially expressed genes encoding transcription-associated proteins in artesunate-treated cells

From: Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate

Gene ID Description Pfam annotation ART 90 min ART 3 h HS CQ
PF11_0053 PfSNF2L TAP clustering Nucleosome remodeling::SNF2L   0,82   
PF11_0264 DNA-dependent RNA polymerase TAP clustering MITOCHONDRIAL RNA POLYMERASE   1,02   
PFL0560c minichromosome maintenance protein, putative TAP clustering Minichromosome maintenance protein   0,85   
PFE0090w hypothetical protein, conserved TAP clustering Histone trancription regulator   0,82   
PF11_0297 hypothetical protein TAP clustering CCR4-NOT complex::NOT2   0,86 +  
PFE1245w hypothetical protein, conserved PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar)(PF00642) 1,28 0,91 + +
PF14_0236 hypothetical protein PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar)(PF00642)   0,89 +  
PFC0680w hypothetical protein, conserved PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar)(PF00642)   1,55 +  
PF10_0186 hypothetical protein PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar)(PF00642)   0,98   
MAL13P1.122 hypothetical protein, conserved PF00856 SET domain (PF00856)   0,81   
PFI0470w FHA domain protein, putative PF00097 C3HC4 type (RING finger) (PF00097) 0,89 1,05   
PF10_0046 hypothetical protein PF00097 C3HC4 type (RING finger) (PF00097)   1,17   
PFF0165c hypothetical protein, conserved PF00097 C3HC4 type (RING finger) (PF00097)   0,94   
PFL0440c hypothetical protein, conserved PF00097 C3HC4 type (RING finger) (PF00097)   0,95   
PF11_0315 hypothetical protein TAP clustering APICOPLAST RNA beta, beta, & beta subunits   1,64   
PFL0145c high mobility group protein PF00505 HMG (high mobility group) box (PF00505)   -0,97   
MAL13P1.76 TFIIH basal transcription factor subunit TAP clustering TFIIH::p44   -0,83   
PF14_0718 hypothetical protein, conserved TAP clustering RNA polymerase II-associated factor SOH1   -0,86   
  1. Gene ID: identifier as found in PlasmoDB.
  2. Art columns: log ratios of gene expression under artesunate exposure at 90 minutes and 3 hours.
  3. HS and CQ columns: over (+) expression.
  4. Results were compared with transcriptome modifications induced by heat-shock (HS) [12] and chloroquine (CQ) [8].
  5. Genes encoding transcription-associated proteins (TAPs) were selected from the TAP clustering of Coulson et al. [17] and completed with an update of genes fitting the following HMM profiles defined by Coulson and colleagues [16] : PF00097, PF00642, PF00096, PF00856, PF00249, PF00439, PF00505, PF00628, PF00098, PF00808, PF01753, PF00313, PF00569, PF00643, PF08523, PF02146, PF03366.