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Table 2 Similarity of gene regulation between P. pastoris and S. cerevisiae upon DTT treatment

From: Novel insights into the unfolded protein response using Pichia pastoris specific DNA microarrays

Function Subfunction No. of similarly regulated/total % similar regulation
Translocation total 4/6 67
Glycosylation total 11/22 50
  Core oligosaccharide synthesis 3/4 75
  Oligosaccharyltransferase 4/4 100
  Glycoprotein processing 1/5 20
  GPI anchoring 1/4 25
  Golgi/O-linked 2/5 40
Protein Folding total 5/8 63
  Chaperones 3/5 60
  Disulfide bond formation 2/3 67
Protein Degradation total 4/5 80
  ERAD 3/3 100
  Ubiquitin/Proteasome 1/2 50
Transport total 11/20 55
  Budding (ER-Golgi) 4/7 57
  Fusion (ER-Golgi) 1/1 100
  Retrieval (ER-Golgi) 4/5 80
  Distal secretion 2/7 29
Lipid Metabolism total 5/18 28
  Fatty acid metabolism 0/4 0
  Heme biosynthesis 2/5 40
  Phospholipid biosynthesis 2/6 33
  Sphingolipid biosynthesis 0/1 0
  Sterol metabolism 1/2 50
Vacuolar Protein Sorting total 1/4 25
Cell Wall Biogenesis total 4/10 40
  1. All genes that were indicated in [17] as core UPR genes in S. cerevisiae and having an annotation in P. pastoris were grouped by their GO process functions. Similar regulation of a gene means upregulated, downregulated or below cut-off, respectively, in both yeasts.