Table 2 Similarity of gene regulation between P. pastoris and S. cerevisiae upon DTT treatment
From: Novel insights into the unfolded protein response using Pichia pastoris specific DNA microarrays
Function | Subfunction | No. of similarly regulated/total | % similar regulation |
|---|---|---|---|
Translocation | total | 4/6 | 67 |
Glycosylation | total | 11/22 | 50 |
Core oligosaccharide synthesis | 3/4 | 75 | |
Oligosaccharyltransferase | 4/4 | 100 | |
Glycoprotein processing | 1/5 | 20 | |
GPI anchoring | 1/4 | 25 | |
Golgi/O-linked | 2/5 | 40 | |
Protein Folding | total | 5/8 | 63 |
Chaperones | 3/5 | 60 | |
Disulfide bond formation | 2/3 | 67 | |
Protein Degradation | total | 4/5 | 80 |
ERAD | 3/3 | 100 | |
Ubiquitin/Proteasome | 1/2 | 50 | |
Transport | total | 11/20 | 55 |
Budding (ER-Golgi) | 4/7 | 57 | |
Fusion (ER-Golgi) | 1/1 | 100 | |
Retrieval (ER-Golgi) | 4/5 | 80 | |
Distal secretion | 2/7 | 29 | |
Lipid Metabolism | total | 5/18 | 28 |
Fatty acid metabolism | 0/4 | 0 | |
Heme biosynthesis | 2/5 | 40 | |
Phospholipid biosynthesis | 2/6 | 33 | |
Sphingolipid biosynthesis | 0/1 | 0 | |
Sterol metabolism | 1/2 | 50 | |
Vacuolar Protein Sorting | total | 1/4 | 25 |
Cell Wall Biogenesis | total | 4/10 | 40 |